Red Sox vs. Guardians Dunkel MLB Picks, Predictions and Prop Bets - Sept. 23

The Cleveland Guardians aim to add to their six-game winning streak when they take on the Boston Red Sox on Wednesday at 7:10 p.m. ET, at Fenway Park. Sonny Gray (17-5, 2.82 ERA) will start for the Red Sox, who are 84-73 this season and third in the AL East. Foster Griffin (15-5, 3.67 ERA) is the expected starter for the Guardians, who are 82-75 and first in the AL Central.

The Guardians (+113) take their show on the road to face the favored Red Sox (-136). The over/under in this contest is 6.5.

Red Sox vs. Guardians Odds, Game Time

• Game day: Wednesday, September 23, 2026
• Game time: 7:10 p.m. ET
• Location: Boston, Massachusetts
• Stadium: Fenway Park
• Favorite: Red Sox (-136)
• Underdog: Guardians (+113)
• Over/under: 6.5

How to Watch Red Sox vs. Guardians

• TV Channel: ESPN
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Red Sox vs. Guardians: Betting the Moneyline

• The Red Sox have gone 60-50 in games they were listed as the moneyline favorite (winning 54.5% of those games).
• Cleveland has won in 29, or 49.2%, of the 59 contests it has been named as odds-on underdogs in this year.
• Boston has entered 60 games this season favored by -136 or more and is 32-28 in those contests.
• This season, the Guardians have been victorious 16 times in 29 chances when named as an underdog of at least +113 or worse on the moneyline.
• The Red Sox have an implied moneyline win probability of 57.6% in this game.
• The Guardians have an implied victory probability of 46.9% according to the moneyline set by oddsmakers for this matchup.

Red Sox vs. Guardians: Betting the Spread & Total

• The Red Sox have played in 157 games with set over/under, and have combined with opponents to go over the total 69 times (69-83-5).
• So far this season, Cleveland and its opponents have hit the over in 75 of its 157 games with a total.
• The Red Sox have a 75-82-0 record against the spread this season (covering 47.8% of the time).
• The Guardians are 75-82-0 against the spread in their 157 games that had a posted line this season.