Red Sox vs. Guardians Dunkel MLB Picks, Predictions and Prop Bets - Sept. 22

The Boston Red Sox will look to Trevor Story, riding an 11-game hitting streak, versus the Cleveland Guardians at 6:45 p.m. ET on Tuesday, at Fenway Park. Payton Tolle (9-6, 3.02 ERA) gets the start for the Red Sox, who are 84-72 this season and third in the AL East. Parker Messick (12-9, 2.57 ERA) is starting for the Guardians, who are 81-75 and first in the AL Central.

The Red Sox (-129) are moneyline favorites at home over the Guardians (+107). The total for this contest is 6.5.

Red Sox vs. Guardians Odds, Game Time

• Game day: Tuesday, September 22, 2026
• Game time: 6:45 p.m. ET
• Location: Boston, Massachusetts
• Stadium: Fenway Park
• Favorite: Red Sox (-129)
• Underdog: Guardians (+107)
• Over/under: 6.5

How to Watch Red Sox vs. Guardians

• TV Channel: NESN and CLEG
• Live Stream: Fubo (Watch for free)

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Red Sox vs. Guardians: Betting the Moneyline

• The Red Sox have been the moneyline favorite 109 total times this season. They've finished 60-49 in those games.
• Cleveland has come away with 28 wins in the 58 contests it has been listed as the underdogs in this season.
• Boston is 40-34 this season when entering a game favored by -129 or more on the moneyline.
• This season, the Guardians have been victorious 21 times in 38 chances when named as an underdog of at least +107 or longer on the moneyline.
• The Red Sox have an implied moneyline win probability of 56.3% in this game.
• Bookmakers have implied with the moneyline set for this matchup that the Guardians have a 48.3% chance of pulling out a win.

Red Sox vs. Guardians: Betting the Spread & Total

• The Red Sox have played in 156 games with a set over/under, and have combined with their opponents to go over the total 69 times (69-82-5).
• Cleveland and its opponents have hit the over in 75 of its 156 games with a total this season.
• The Red Sox have covered 48.1% of their games this season, going 75-81-0 ATS.
• The Guardians have an against the spread mark of 74-82-0 in 156 games with a line this season.