Cardinals vs. Giants Dunkel MLB Picks, Predictions and Prop Bets - Sept. 16

The St. Louis Cardinals and San Francisco Giants play a rubber match on Wednesday at 1:15 p.m. ET, with the series deadlocked at 1-1. Matthew Liberatore (5-14, 5.53 ERA) gets the start for the Cardinals, who are 75-77 this season and fourth in the NL Central. Anthony Molina (3-1, 5.24 ERA) is expected to start for the Giants, who are 63-89 and fourth in the NL West.

The Cardinals (-167) are moneyline favorites at home over the Giants (+136). The over/under for this contest is set at 8.

Cardinals vs. Giants Odds, Game Time

• Game day: Wednesday, September 16, 2026
• Game time: 1:15 p.m. ET
• Location: St. Louis, Missouri
• Stadium: Busch Stadium
• Favorite: Cardinals (-167)
• Underdog: Giants (+136)
• Over/under: 8

How to Watch Cardinals vs. Giants

• TV Channel: CARD and NBCS-BA
• Live Stream: Fubo (Watch for free)

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Cardinals vs. Giants: Betting the Moneyline

• The Cardinals have compiled a 26-24 record in games they were favored on the moneyline (winning 52% of those games).
• San Francisco has come away with 38 wins in the 102 contests it has been listed as the underdogs in this season.
• St. Louis has played as favorites of -167 or more twice this season and split those games.
• This season, the Giants have been victorious 15 times in 31 chances when named as an underdog of at least +136 or worse on the moneyline.
• The Cardinals have a 62.5% chance to win this game based on the moneyline's implied probability.
• Sportsbooks have implied with the moneyline set for this matchup that the Giants have a 42.4% chance of pulling out a win.

Cardinals vs. Giants: Betting the Spread & Total

• The Cardinals have combined with opponents to go over the total 67 times this season for a 67-75-10 record against the over/under.
• San Francisco's games have gone over the total in 73 of its 151 chances.
• The Cardinals have put together an 84-68-0 record against the spread this season (covering 55.3% of the time).
• The Giants have posted a record of 76-75-0 against the spread this season.