Cardinals vs. Giants Dunkel MLB Picks, Predictions and Prop Bets - Sept. 15

The San Francisco Giants will look to snap a four-game losing streak when visiting the St. Louis Cardinals at 7:45 p.m. ET on Tuesday. Andre Pallante (12-6, 3.45 ERA) will start for the Cardinals, who are 75-76 this season and fourth in the NL Central. Blade Tidwell (0-2, 4.82 ERA) is expected to start for the Giants, who are 62-89 and fourth in the NL West.

At home, the Cardinals are favored to win on the moneyline (-166) over the Giants (+135). The game's total is 8.5.

Cardinals vs. Giants Odds, Game Time

• Game day: Tuesday, September 15, 2026
• Game time: 7:45 p.m. ET
• Location: St. Louis, Missouri
• Stadium: Busch Stadium
• Favorite: Cardinals (-166)
• Underdog: Giants (+135)
• Over/under: 8.5

How to Watch Cardinals vs. Giants

• TV Channel: CARD and NBCS-BA
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Cardinals vs. Giants: Betting the Moneyline

• The Cardinals have a 26-23 record in games they were favored on the moneyline (winning 53.1% of those games).
• San Francisco has come away with 37 wins in the 101 contests it has been listed as the underdogs in this season.
• St. Louis has played as favorites of -166 or more once this season and won that game.
• The Giants have a win-loss record of 14-17 when favored by +135 or worse by bookmakers this year.
• Based on this matchup's moneyline, the Cardinals have an implied win probability of 62.4%.
• The moneyline set for this matchup implies the Giants have a 42.6% chance of coming away with a victory in the contest.

Cardinals vs. Giants: Betting the Spread & Total

• The Cardinals have played in 151 games with set over/under, and have combined with opponents to go over the total 66 times (66-75-10).
• So far this season, San Francisco and its opponents have hit the over in 72 of its 150 games with a total.
• The Cardinals have an 84-67-0 record against the spread this season.
• The Giants are 75-75-0 against the spread in their 150 games with a line set by sportsbooks this season.