Seahawks vs. Cardinals Week 2 Dunkel NFL Picks, Predictions and Odds

The Seattle Seahawks (1-0) and Arizona Cardinals (1-0) will meet in a battle of two division rivals. The Seahawks are the favorites, expected to win by at least a field goal but less than a touchdown (currently -4.5). The expected point total for the matchup is 41.5.

The Seahawks totaled 351.4 yards per game on offense last season (seventh in NFL), and they ranked sixth on defense with 285.9 yards allowed per game. The Cardinals ranked 19th in total offense (325.8 yards per game) and 27th in total defense (357.7 yards allowed per game) last season.

Seahawks vs. Cardinals Odds and Game Time

• Date: Sunday, September 20, 2026
• Time: 4:25 p.m. ET
• City: Glendale, Arizona
• Venue: State Farm Stadium
• Total: 41.5 points
• Spread: Seahawks -4.5
• Moneyline: Seahawks (-218), Cardinals (+180)

How to watch Seahawks vs. Cardinals

• TV Channel: FOX

Betting the Over/Under: Seahawks vs. Cardinals

• The Seahawks' 17 games last season went over this contest's total of 41.5 points 10 times.
• Seahawks games went over the point total nine out of 17 times last season.
• The Cardinals and their opponents combined to score more than 41.5 points in 14 of 17 games last season.
• Arizona games went over the point total 10 out of 17 times last year.
• These two teams racked up a combined 49.3 points per game last season, 7.8 more points than this matchup's point total.
• Opponents of these two teams averaged 45.9 combined points per game last season, 4.4 more than the total for this matchup.

Betting the Spread: Seahawks vs. Cardinals

• Seattle won 12 games against the spread last season, failing to cover five times.
• Seattle was 5-2 ATS last season when playing as at least 4.5-point favorites.
• The Cardinals compiled a 6-11-0 record against the spread last year.
• Arizona covered the spread twice when an underdog by 4.5 points or more last season (in seven opportunities).
• The Cardinals covered the spread once at home, and were 1-7 overall there, last season.
• Arizona had one win ATS (1-1) as 4.5-point underdogs or more at home last year.
• Away from home last season, the Seahawks were 8-1 against the spread, and 8-1 overall.
• Seattle had two wins ATS (2-1) on the road as 4.5-point favorites or more.

Betting the Moneyline: Seahawks vs. Cardinals

• Seattle put together a 13-1 record in games it was listed as the moneyline favorite last season (winning 92.9% of those games).
• The Cardinals were underdogs in 14 games last season and won one (7.1%) of those contests.
• Seattle won all seven games it played as a moneyline favorite with odds of -218 or shorter.
• Last season, Arizona was at least a +180 underdog on the moneyline seven times, losing each of those contests.
• The Seahawks have an implied moneyline win probability of 68.6% in this game.

Dunkel Prediction for Seahawks vs. Cardinals

For more expert NFL picks, visit our Dunkel Index NFL Picks and Predictions.