Seahawks vs. Cardinals Week 2 Dunkel NFL Picks, Predictions and Odds

The Seattle Seahawks (1-0) are the favorites -- expected to win by at least a field goal, but less than a touchdown (currently -3.5) -- against the Arizona Cardinals (1-0) in a matchup of two division rivals. The predicted point total for the matchup is 41.5.

The Seahawks totaled 351.4 yards per game on offense last season (seventh in NFL), and they surrendered 285.9 yards per game (sixth) on the defensive side of the ball. The Cardinals put up 325.8 yards per game on offense last season, which ranked them 19th in the NFL. On the other side of the ball, they ranked 27th, giving up 357.7 yards per contest.

Seahawks vs. Cardinals Odds and Game Time

• Date: Sunday, September 20, 2026
• Time: 4:25 p.m. ET
• City: Glendale, Arizona
• Venue: State Farm Stadium
• Total: 41.5 points
• Spread: Seahawks -3.5
• Moneyline: Seahawks (-225), Cardinals (+185)

How to watch Seahawks vs. Cardinals

• TV Channel: FOX

Betting the Over/Under: Seahawks vs. Cardinals

• The Seahawks and their opponents went over 41.5 combined points in 10 of 17 games last season.
• The Seahawks and their opponents combined to hit the over nine out of 17 times last season.
• Arizona played 14 games last season that finished with a combined score over 41.5 points.
• Arizona games hit the over 10 out of 17 times last season.
• The two teams combined to score 49.3 points per game last season, 7.8 more points than this matchup's total.
• These teams allowed a combined 45.9 points per game last year, 4.4 more points than the over/under for this matchup.

Betting the Spread: Seahawks vs. Cardinals

• Seattle won 12 games against the spread last season, failing to cover five times.
• Seattle covered the spread five times last season (5-3 ATS) when playing as at least 3.5-point favorites.
• The Cardinals compiled a 6-11-0 record against the spread last year.
• When playing as at least 3.5-point underdogs last season, Arizona had an ATS record of 4-6.
• The Cardinals covered the spread once at home, and were 1-7 overall there, last season.
• Arizona had one win ATS (1-2) as 3.5-point underdogs or more at home last year.
• The Seahawks were 8-1 against the spread, and 8-1 overall, away from home last season.
• Seattle had two wins ATS (2-1) on the road as 3.5-point favorites or more.

Betting the Moneyline: Seahawks vs. Cardinals

• Seattle finished with a 13-1 record in games it was listed as the moneyline favorite last season (winning 92.9% of those games).
• The Cardinals were underdogs 14 times last season and won once.
• Seattle won all seven games it played as a moneyline favorite with odds of -225 or shorter.
• Last season, Arizona was at least a +185 underdog on the moneyline seven times, losing each of those contests.
• Based on this contest's moneyline, the Seahawks' implied win probability is 69.2%.

Dunkel Prediction for Seahawks vs. Cardinals

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