Santa Clara vs. Loyola Chicago Dunkel Predictions & Vegas Odds - Dec. 20

The Santa Clara Broncos (9-3) host the Loyola Chicago Ramblers (3-9) at Kaiser Permanente Arena, beginning at 5 p.m. ET on Saturday, December 20, 2025. The Broncos are 15.5-point favorites in the game. The matchup has an over/under set at 149.5 points.

Santa Clara is coming off of a 63-60 victory over North Texas in its most recent outing on Wednesday. In Santa Clara's win, Elijah Mahi led the way with a team-high 17 points (adding five rebounds and four assists). Loyola Chicago's most recent game was an 85-71 loss to San Francisco on Wednesday. Xavier Amos scored a team-high 17 points for Loyola Chicago in the loss.

Santa Clara vs. Loyola Chicago Odds and Game Time

• When: Saturday, December 20, 2025 at 5 p.m. ET
• Where: Kaiser Permanente Arena in Santa Cruz, California
• Spread favorite: Santa Clara -15.5
• Moneyline favorite: Santa Clara -1724
• Moneyline underdog: Loyola Chicago +941
• Over/Under: 149.5 points

How to watch Santa Clara vs. Loyola Chicago

• TV Channel: BallerTV
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Santa Clara vs. Loyola Chicago

• Santa Clara and its opponents have hit the over on this game's total (149.5 points) six times this season.
• There have been five Loyola Chicago games that finished with a combined score over 149.5 points this season.
• The Broncos average 79.2 points per game against the Ramblers' 68.5, amounting to 1.8 points under the matchup's total of 149.5.
• This matchup's point total is 3.2 fewer points than the 146.3 these two teams combine to allow per game in 2024.
• This season the average over/under for Santa Clara's games is 148.8 points, 0.7 lower than the over/under of 149.5 points set for this contest.
• The over/under for this game is 4.3 points higher than the average over/under in Loyola Chicago's games this season of 145.2.

Betting the Spread: Santa Clara vs. Loyola Chicago

• Against the spread, Santa Clara is 6-5-0 this season.
• This season, the Broncos have just one against the spread win in three games as a favorite of 15.5 points or more.
• Loyola Chicago has one win against the spread in 12 games this year.
• At home this year, Santa Clara is 3-2 against the spread and 5-0 overall.
• At home, Santa Clara has one win ATS (1-2) as a 15.5-point favorite or more.

Betting the Moneyline: Santa Clara vs. Loyola Chicago

• This season, Santa Clara has won seven out of the nine games in which it has been the moneyline favorite.
• The Broncos have entered three games this season favored by -1724 or more, and won each of those games.
• The moneyline for this contest implies a 94.5% chance of a victory for Santa Clara.
• Loyola Chicago has been named as the moneyline underdog five times this season but has yet to come away with a victory in any of those games.
• This is the worst odds of a win that sportsbooks have given the Ramblers this season with a +941 moneyline set for this game.
• Oddsmakers have implied with the moneyline set for this matchup that Loyola Chicago has a 9.6% chance of pulling out a win.

Dunkel Index Prediction for Santa Clara vs. Loyola Chicago

• Pick ATS: Santa Clara (- 15.5)
• Pick OU: Under (149.5)
  
• Prediction: Santa Clara 86 - Loyola Chicago 60