Giants vs. Padres Dunkel MLB Picks, Predictions and Prop Bets - May 6

Casey Schmitt takes a two-game homer streak into the San Francisco Giants' game against the San Diego Padres at 3:45 p.m. ET on Wednesday, at Oracle Park. Adrian Houser (0-3, 7.12 ERA) gets the start for the Giants, who are 14-22 this season and fourth in the NL West. Matt Waldron (0-1, 9.88 ERA) is the expected starter for the Padres, who are 21-14 and second in the NL West.

The Giants (-145) are moneyline favorites at home over the Padres (+121). The total for the Giants-Padres game is 7.5.

Giants vs. Padres Odds, Game Time

• Game day: Wednesday, May 6, 2026
• Game time: 3:45 p.m. ET
• Location: San Francisco, California
• Stadium: Oracle Park
• Favorite: Giants (-145)
• Underdog: Padres (+121)
• Over/under: 7.5

How to Watch Giants vs. Padres

• TV Channel: NBCS-BA and SDPA
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Giants vs. Padres: Betting the Moneyline

• The Giants have put together a 5-7 record in games they were listed as the moneyline favorite (winning 41.7% of those games).
• San Diego has been underdogs in 13 games this season and has come away with the win seven times (53.8%) in those contests.
• San Francisco has played as favorites of -145 or more twice this season and split those games.
• This season, the Padres have been victorious two times in three chances when named as an underdog of at least +121 or longer on the moneyline.
• Based on this game's moneyline, the Giants' implied win probability is 59.2%.
• Oddsmakers have implied with the moneyline set for this matchup that the Padres have a 45.2% chance of pulling out a win.

Giants vs. Padres: Betting the Spread & Total

• In the 36 games in which bookmakers have set an over/under for the Giants, they have combined with opponents to go over the total 15 times (15-18-3).
• So far this season, San Diego and its opponents have hit the over in 16 of its 35 games with a total.
• The Giants have a 15-21-0 record ATS this season.
• The Padres are 20-15-0 against the spread in their 35 games that had a posted line this season.