49ers vs. Titans Week 15 Dunkel NFL Picks, Predictions and Odds

Having won three in a row, the San Francisco 49ers (9-4) will face the Tennessee Titans (2-11). The 49ers are heavy favorites (-12.5). The expected point total for the matchup is set at 44.5.

The 49ers rank 11th in total offense (341.2 yards per game) and 20th in total defense (335.8 yards allowed per game) this year. The Titans rank worst in total yards per game (246.2), but they've been more effective on the defensive side of the ball, ranking 26th in the NFL with 350.9 total yards allowed per contest.

49ers vs. Titans Odds and Game Time

• Date: Sunday, December 14, 2025
• Time: 4:25 p.m. ET
• City: Santa Clara, California
• Venue: Levi's Stadium
• Total: 44.5 points
• Spread: 49ers -12.5
• Moneyline: 49ers (-952), Titans (+625)

How to watch 49ers vs. Titans

• TV Channel: FOX (KRXI- Reno, NV)
• Live Stream: Fubo

Betting the Over/Under: 49ers vs. Titans

• 49ers games this season have featured more combined points than this contest's total of 44.5 points seven times.
• San Francisco and its opponent have combined to hit the over seven out of 13 times this season.
• Titans games this season have had a combined scoring total higher than 44.5 points in six of 13 outings.
• In 2025, eight Tennessee games have hit the over.
• These two teams average 39.1 points per game combined, 5.4 less than this game's total.
• Opponents of these two teams average 48.2 combined points per game, 3.7 more points than this matchup's over/under.

Betting the Spread: 49ers vs. Titans

• San Francisco has covered the spread eight times in 13 games this season.
• The Titans have won six games against the spread this year, failing to cover seven times.
• Tennessee has not covered the spread this season (0-1 ATS) when playing as at least 12.5-point underdogs.
• The 49ers have two wins against the spread, and are 3-2 overall, at home this year.
• The Titans are 3-3 against the spread, and 2-4 overall, on the road.
• On the road, Tennessee is winless ATS (0-1) as 12.5-point underdogs or more.

Betting the Moneyline: 49ers vs. Titans

• San Francisco has an 8-1 record in games they were listed as the moneyline favorite (winning 88.9% of those games).
• The Titans have been underdogs in 13 games this season and won two (15.4%) of those contests.
• San Francisco has yet to play as a moneyline favorite of -952 or shorter.
• Tennessee has been at least a +625 moneyline underdog two times this season, but lost all of those games.
• The 49ers have a 90.5% chance to win this contest based on the moneyline's implied probability.

Dunkel Prediction for 49ers vs. Titans

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