49ers vs. Dolphins Week 2 Dunkel NFL Picks, Predictions and Odds

The San Francisco 49ers (1-0) are considered favorites (-13.5) according to the bookmakers ahead of their game against the Miami Dolphins (0-1) on September 20, 2026, starting at 4:25 p.m. ET, airing on FOX. The matchup has an over/under of 45.5 points.

Offensively, the 49ers ranked 10th in the NFL with 25.7 points per game last season. Meanwhile, they ranked 13th in points allowed (340.2 points allowed per contest). The Dolphins totaled 300.7 yards per game offensively last season (26th in NFL), and they surrendered 348.8 yards per game (22nd) on the other side of the ball.

49ers vs. Dolphins Odds and Game Time

• Date: Sunday, September 20, 2026
• Time: 4:25 p.m. ET
• City: Santa Clara, California
• Venue: Levi's Stadium
• Total: 45.5 points
• Spread: 49ers -13.5
• Moneyline: 49ers (-901), Dolphins (+600)

How to watch 49ers vs. Dolphins

• TV Channel: FOX

Betting the Over/Under: 49ers vs. Dolphins

• In 10 of 17 games last season, the 49ers and their opponents combined to total more than 45.5 points.
• A total of 10 of the 49ers' games last season hit the over.
• Miami played seven games last season that finished with a combined score over 45.5 points.
• Miami games hit the over 10 out of 17 times last year.
• The teams combined to score 46.1 points per game last season, 0.6 more points than the over/under for this matchup.
• Opponents of these teams scored 46.7 combined points per game last season, 1.2 more than the over/under for this matchup.

Betting the Spread: 49ers vs. Dolphins

• San Francisco won 11 games against the spread last season, failing to cover six times.
• The Dolphins won eight games against the spread last year, while failing to cover nine times.
• Miami did not cover the spread last season (0-1 ATS) when playing as at least 13.5-point underdogs.
• At home last year, the 49ers were 4-4 against the spread and 5-3 overall.
• On the road last season, the Dolphins were 3-5 against the spread, and 2-6 overall.
• Miami was winless ATS (0-1) as 13.5-point underdogs or more on the road.

Betting the Moneyline: 49ers vs. Dolphins

• San Francisco was favored on the moneyline 12 total times last season. They went 11-1 in those games.
• Last season, the Dolphins were the underdog 11 times and won three, or 27.3%, of those games.
• San Francisco played as a moneyline favorite of -901 or shorter in only one game last season, which it won.
• Last season, Miami was at least a +600 underdog on the moneyline one time, losing that contest.
• The implied moneyline probability in this matchup gives the 49ers a 90.0% chance to win.

Dunkel Prediction for 49ers vs. Dolphins

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