49ers vs. Dolphins Week 2 Dunkel NFL Picks, Predictions and Odds

The San Francisco 49ers (1-0) are considered favorites (-12.5) according to the oddsmakers ahead of their game against the Miami Dolphins (0-1) on September 20, 2026, starting at 4:25 p.m. ET, airing on FOX. The total for this one is set at 45.5 points.

The 49ers totaled 351.4 yards per game on offense last season, which ranked them seventh in the NFL. On defense, they ranked 20th, allowing 340.2 yards per contest. The Dolphins averaged 300.7 yards per game offensively last season (26th in NFL), and they allowed 348.8 yards per game (22nd) on the defensive side of the ball.

49ers vs. Dolphins Odds and Game Time

• Date: Sunday, September 20, 2026
• Time: 4:25 p.m. ET
• City: Santa Clara, California
• Venue: Levi's Stadium
• Total: 45.5 points
• Spread: 49ers -12.5
• Moneyline: 49ers (-952), Dolphins (+625)

How to watch 49ers vs. Dolphins

• TV Channel: FOX

Betting the Over/Under: 49ers vs. Dolphins

• The 49ers' 17 games last season went over this contest's total of 45.5 points 10 times.
• A total of 10 of the 49ers' games last season went over the point total.
• The Dolphins' games last season had a combined scoring total higher than 45.5 points in seven of 17 outings.
• In Miami games last year, combined scoring went over the point total 10 times.
• The teams combined to score 46.1 points per game last season, 0.6 more points than the over/under for this matchup.
• Opponents of these teams put up 46.7 combined points per game last season, 1.2 more than the over/under for this matchup.

Betting the Spread: 49ers vs. Dolphins

• San Francisco went 11-6-0 ATS last season.
• San Francisco won its only game last season when playing as at least 12.5-point favorites.
• The Dolphins won eight games against the spread last season, while failing to cover nine times.
• Miami was an underdog by 12.5 points or more two times last year, and covered the spread in one of those contests.
• At home last year, the 49ers were 4-4 against the spread and 5-3 overall.
• San Francisco was unbeaten ATS (1-0) as 12.5-point favorites or more at home last season.
• In away games last season, the Dolphins were 2-6 overall and 3-5 against the spread.
• Miami had one win ATS (1-1) as 12.5-point underdogs or more away from home.

Betting the Moneyline: 49ers vs. Dolphins

• San Francisco finished with an 11-1 record in games it was listed as the moneyline favorite last season (winning 91.7% of those games).
• The Dolphins were underdogs 11 times last season and won three, or 27.3%, of those games.
• San Francisco played as a moneyline favorite of -952 or shorter in just one game last season, which it won.
• Last season, Miami was at least a +625 underdog on the moneyline one time, losing that contest.
• Based on this game's moneyline, the 49ers have an implied win probability of 90.5%.

Dunkel Prediction for 49ers vs. Dolphins

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