49ers vs. Cardinals Week 3 Dunkel NFL Picks, Predictions and Odds

The San Francisco 49ers (2-0) are slim favorites (-1.5) against the Arizona Cardinals (2-0) in a matchup of two division rivals. The expected point total for the matchup is 44.5.

Offensively, the 49ers rank 18th in the NFL with 21.5 points per game. Meanwhile, they rank seventh in points allowed (268.5 points allowed per contest). With 23.5 points per game on the offensive side of the ball, the Cardinals rank 11th in the NFL. On defense, they rank 10th, giving up 17.5 points per contest.

49ers vs. Cardinals Odds and Game Time

• Date: Sunday, September 21, 2025
• Time: 4:25 p.m. ET
• City: Santa Clara, California
• Venue: Levi's Stadium
• Total: 44.5 points
• Spread: 49ers -1.5
• Moneyline: 49ers (-125), Cardinals (+105)

How to watch 49ers vs. Cardinals

• TV Channel: FOX (KNIN-Boise, ID)
• Live Stream: Fubo

Betting the Over/Under: 49ers vs. Cardinals

• So far this season, one San Francisco game has gone over the point total.
• So far this year, one Arizona game has hit the over.
• The two teams combine to score 45 points per game, 0.5 more points than this matchup's total.
• Opponents of these teams score 34.5 points per game combined, 10.0 fewer than this matchup's over/under.

Betting the Spread: 49ers vs. Cardinals

• San Francisco has covered in each of its two games with a spread this season.
• San Francisco has been favored by 1.5 points or more two times this season, and covered the spread in both.
• The Cardinals have won one game against the spread this season.

Betting the Moneyline: 49ers vs. Cardinals

• San Francisco has been the moneyline favorite just two other times so far this season, and they won both of the games.
• This is the first time the Cardinals will play as underdogs this season.
• San Francisco has played as a moneyline favorite of -125 or shorter in only two games this season, and it won both.
• Arizona has not entered a game this season with longer moneyline odds than +105.
• The 49ers have an implied moneyline win probability of 55.6% in this contest.

Dunkel Prediction for 49ers vs. Cardinals

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