Padres vs. Giants Dunkel MLB Picks, Predictions and Prop Bets - May 4

The San Diego Padres and San Francisco Giants clash in the first of a three-game series on Monday at Oracle Park, at 9:45 p.m. ET. Randy Vasquez (3-0, 2.94 ERA) will start for the Padres, who are 20-13 this season and second in the NL West. Trevor McDonald (0-0, 0.00 ERA) is expected to start for the Giants, who are 13-21 and fifth in the NL West.

Despite playing on the road, the Padres are still a decent moneyline favorite (-136) over the Giants (+114). The game's total is set at 8.

Padres vs. Giants Odds, Game Time

• Game day: Monday, May 4, 2026
• Game time: 9:45 p.m. ET
• Location: San Francisco, California
• Stadium: Oracle Park
• Favorite: Padres (-136)
• Underdog: Giants (+114)
• Over/under: 8

How to Watch Padres vs. Giants

• TV Channel: NBCS-BA and SDPA
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Padres vs. Giants: Betting the Moneyline

• The Padres have gone 12-7 in games they were favored on the moneyline (winning 63.2% of those games).
• San Francisco has come away with eight wins in the 23 contests it has been listed as the underdogs in this season.
• San Diego has a record of 9-3, a 75% win rate, when favored by -136 or more by oddsmakers this season.
• The Giants have a mark of 3-6 in contests where oddsmakers favor them by +114 or worse on the moneyline.
• The Padres have a 57.6% chance to win this contest based on the moneyline's implied probability.
• Bookmakers have implied with the moneyline set for this matchup that the Giants have a 46.7% chance of pulling out a win.

Padres vs. Giants: Betting the Spread & Total

• The Padres have played in 33 games with a set over/under, and have combined with their opponents to go over the total 15 times (15-16-2).
• Games involving San Francisco have gone over the total set by oddsmakers in 14 of 34 chances this season.
• The Padres have covered 57.6% of their games this season, going 19-14-0 ATS.
• The Giants are 14-20-0 against the spread in their 34 games that had a posted line this season.