Padres vs. Cubs Dunkel MLB Picks, Predictions and Prop Bets - April 27

Luis Campusano takes a two-game homer streak into the San Diego Padres' game versus the Chicago Cubs at 9:40 p.m. ET on Monday, at Petco Park. Randy Vasquez (2-0, 1.88 ERA) gets the start for the Padres, who are 18-9 this season and second in the NL West. Matthew Boyd (1-1, 5.79 ERA) is starting for the Cubs, who are 17-11 and second in the NL Central.

The moneyline odds for the Padres (-118) versus the Cubs (-101) are tight. The contest has a total set at 7.5.

Padres vs. Cubs Odds, Game Time

• Game day: Monday, April 27, 2026
• Game time: 9:40 p.m. ET
• Location: San Diego, California
• Stadium: Petco Park
• Favorite: Padres (-118)
• Underdog: Cubs (-101)
• Over/under: 7.5

How to Watch Padres vs. Cubs

• TV Channel: SDPA and MARQ
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Padres vs. Cubs: Betting the Moneyline

• The Padres have gone 10-4 in games they were favored on the moneyline (winning 71.4% of those games).
• Chicago has been underdogs in 10 games this season and has come away with the win six times (60%) in those contests.
• This season San Diego has won nine of its 13 games, or 69.2%, when favored by at least -118 on the moneyline.
• The Cubs have a win-loss record of 4-4 when favored by -101 or worse by bookmakers this year.
• Based on this matchup's moneyline, the Padres have an implied win probability of 54.1%.
• The Cubs have an implied victory probability of 50.2% according to the moneyline set for this matchup.

Padres vs. Cubs: Betting the Spread & Total

• In the 27 games in which oddsmakers have set an over/under for the Padres, they have combined with opponents to go over the total 11 times (11-14-2).
• Chicago and its opponents have hit the over in 17 of its 28 games with a total this season.
• The Padres have a 17-10-0 record against the spread this season.
• In 28 games with a line this season, the Cubs have a mark of 14-14-0 against the spread.