Purdue vs. Iowa State Dunkel Predictions & Vegas Odds - Dec. 6

The No. 1 Purdue Boilermakers (8-0) host the No. 10 Iowa State Cyclones (8-0) at Mackey Arena, tipping off at 12 p.m. ET on Saturday, December 6, 2025. The Cyclones are 5.5-point underdogs in the game. The matchup has an over/under set at 150.5 points.

In its most recent outing on Tuesday, Purdue earned an 81-65 win over Rutgers. Trey Kaufman-Renn scored a team-leading 19 points for Purdue in the win. Iowa State heads into this game on the heels of a 132-68 win against Alcorn State on Wednesday. Milan Momcilovic's team-high 27 points paced Iowa State in the win.

Purdue vs. Iowa State Odds and Game Time

• When: Saturday, December 6, 2025 at 12 p.m. ET
• Where: Mackey Arena in West Lafayette, Indiana
• Spread favorite: Purdue -5.5
• Over/Under: 150.5 points

How to watch Purdue vs. Iowa State

• TV Channel: MyNetworkTV (KELO – Sioux Falls, SD)
• Live Stream: Fubo
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Purdue vs. Iowa State

• This season, Purdue's games have seen a combined score higher than this matchup's 150.5-point over/under five times.
• This season, six games Iowa State has played finished with a combined score over 150.5 points.
• The total for the contest of 150.5 is 34.4 points fewer than the combined points per game averages for the Boilermakers (88.6) and Cyclones (96.3).
• These two teams give up a combined 133 points per game, 17.5 less than this contest's over/under.
• Purdue has seen a 156.3 average over/under in its games this season, 5.8 points more than the over/under in this matchup.
• A difference of 11.1 points separates the average over/under in Iowa State's games (161.6 points) and this contest's over/under (150.5).

Betting the Spread: Purdue vs. Iowa State

• Purdue has played eight games, with four wins against the spread.
• This season, the Boilermakers have just two against the spread wins in six games as a favorite of 5.5 points or more.
• Iowa State is 6-2-0 against the spread this season.
• Purdue has one win against the spread, and is 4-0 overall, at home this season.
• At home, Purdue has one win ATS (1-3) as a 5.5-point favorite or greater.