Ohio vs. Buffalo Dunkel NCAA Football Picks, Predictions and Odds - Nov. 28

The Ohio Bobcats (7-4) visit the Buffalo Bulls (5-6) on Friday, November 28, 2025 in a matchup between MAC foes at UB Stadium. Buffalo is a touchdown underdog.

The Bobcats won versus the UMass Minutemen in their most recent game, 42-14.

The Bulls lost to the Miami (OH) RedHawks, 37-20, in their most recent contest.

Ohio vs. Buffalo Predictions

For the upcoming contest between the Ohio Bobcats and Buffalo Bulls, computer-derived against-the-spread, over/under, and score predictions are below, based on data from Dunkel Index.

• Pick ATS: Bobcats (- 7)
• Pick OU: Under (44.5)
  
• Prediction: Bobcats 27 - Bulls 12

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Ohio vs. Buffalo Moneylines

Grab a look below at the latest moneylines for the Bobcats-Bulls matchup.

• Ohio Moneyline: -256
• Buffalo Moneyline: +207

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Ohio Betting Insights

• Ohio has gone 6-1 in games it was listed as the moneyline favorite (winning 85.7% of those games).
• In games it has played as a moneyline favorite with odds of -256 or shorter, Ohio has a 5-1 record (winning 83.3% of its games).
• In seven of 11 games this season, the Bobcats and their opponents have combined to total more than 44.5 points.
• The Bobcats have an average total of 52.0 in their outings this year, 7.5 more points than this matchup's over/under.
• The Bobcats score the 62nd-most points in college football this season, while the Bulls' offense racks up the 97th-most.

Buffalo Betting Insights

• Buffalo has been an underdog in five games this season and won one (20%) of those contests.
• Buffalo has played as an underdog of +207 or more once this season and lost that game.
• Buffalo has played six games this season that ended with a combined score higher than 44.5 points.
• Buffalo's average game total this season has been 46.5, 2.0 more points than this matchup's over/under.

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Key Stats for Ohio vs. Buffalo

• In their past four head-to-head contests, Ohio has defeated Buffalo three times.
• In those matchups against Buffalo, the Bobcats have covered four times while outscoring the point total on two occasions.
• The Bobcats are putting up 408.5 yards per game on offense this year (48th in the FBS), and they are surrendering 356.9 yards per game (58th) on the other side of the ball.
• Ohio is totaling 28.5 points per game offensively this year (62nd in the FBS), and is allowing 22.6 points per game (50th) on the defensive side of the ball.
• In terms of total offense, the Bulls rank 88th in the FBS (361.5 total yards per game) and 34th on the other side of the ball (329.5 total yards allowed per game).
• In terms of points scored Buffalo ranks 95th in the FBS (23.8 points per game), and it is 51st on the other side of the ball (22.8 points allowed per game).