Twins vs. Giants Dunkel MLB Picks, Predictions and Prop Bets - Sept. 23

The Minnesota Twins and San Francisco Giants square off on Wednesday at 3:45 p.m. ET at Oracle Park, attempting to break a 1-1 series tie. Connor Prielipp (6-7, 4.94 ERA) gets the start for the Twins, who are 74-84 this season and third in the AL Central. Cesar Perdomo (0-1, 3.72 ERA) is expected to start for the Giants, who are 65-93 and fourth in the NL West.

Despite playing away from home the Twins are at -143 to win, compared to the Giants at +118. The over/under in this contest is set at 7.

Twins vs. Giants Odds, Game Time

• Game day: Wednesday, September 23, 2026
• Game time: 3:45 p.m. ET
• Location: San Francisco, California
• Stadium: Oracle Park
• Favorite: Twins (-143)
• Underdog: Giants (+118)
• Over/under: 7

How to Watch Twins vs. Giants

• TV Channel: NBCS-BA and MNNT
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Twins vs. Giants: Betting the Moneyline

• The Twins have been the moneyline favorite 60 total times this season. They've gone 33-27 in those games.
• San Francisco has been underdogs in 108 games this season and has come away with the win 40 times (37%) in those contests.
• This season Minnesota has won nine of its 17 games, or 52.9%, when favored by at least -143 on the moneyline.
• This season, the Giants have been victorious 20 times in 55 chances when named as an underdog of at least +118 or longer on the moneyline.
• The implied moneyline probablility for this matchup gives the Twins a 58.8% chance to win.
• The moneyline set for this matchup implies the Giants have a 45.9% chance of coming away with a victory in the contest.

Twins vs. Giants: Betting the Spread & Total

• The Twins have had an over/under set by bookmakers 158 times, and have combined with opponents to go over the total in 86 of those games (86-64-8).
• San Francisco's games have gone over the total in 76 of its 157 chances.
• The Twins have covered 52.5% of their games this season, going 83-75-0 ATS.
• In 157 games with a line this season, the Giants have a mark of 79-78-0 against the spread.