Michigan vs. Saint Louis Dunkel Predictions & Vegas Odds - Second Round

The No. 1 seed Michigan Wolverines (32-3) are favored by 12.5 points against the No. 9 seed Saint Louis Billikens (29-5) for their NCAA Tournament matchup on Saturday. A trip to the Sweet 16 will be awarded to the winner of the 1-9 Midwest Region bracket contest, which tips off at 12:10 p.m. ET on CBS. The matchup's point total is 161.5.

In its last matchup on Thursday, Michigan secured a 101-80 win over Howard. In the victory, Morez Johnson Jr. led Michigan with 21 points. In its most recent outing on Thursday, Saint Louis earned a 102-77 win over Georgia. Dion Brown's team-leading 18 points paced Saint Louis in the victory.

Michigan vs. Saint Louis Odds and Game Time

• When: Saturday, March 21, 2026 at 12:10 p.m. ET
• Where: KeyBank Center in Buffalo, New York
• Spread favorite: Michigan -12.5
• Moneyline favorite: Michigan -952
• Moneyline underdog: Saint Louis +602
• Over/Under: 161.5 points

How to watch Michigan vs. Saint Louis

• TV Channel: CBS
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Michigan vs. Saint Louis

• A total of 13 of Michigan's games this season have gone over Saturday's over/under of 161.5 points.
• A total of 12 of Saint Louis' games have finished with a combined score over 161.5 points this season.
• The Wolverines average 87.2 points per game against the Billikens' 87.7, totaling 13.4 points over the contest's over/under of 161.5.
• These two teams give up a combined 139.2 points per game, 22.3 points less than this contest's over/under.
• This season the average over/under for Michigan's games is 156.7 points, 4.8 lower than the over/under of 161.5 points set for this contest.
• The over/under for this game is 4.1 points more than the average over/under in Saint Louis' games this season (157.4 points).

Betting the Spread: Michigan vs. Saint Louis

• Against the spread, Michigan is 16-19-0 this year.
• The Wolverines have an ATS record of 8-14 in their 22 games as a favorite of 12.5 points or more so far this season.
• Against the spread, Saint Louis is 19-14-0 this season.
• Michigan is 9-6 against the spread, and 14-1 overall, at home this year.
• This season, as a 12.5-point favorite or greater at home, Michigan is 8-5 ATS.
• Saint Louis is 7-3 overall, and 5-5 against the spread, away from home.
• Saint Louis has one win ATS (1-1) as 12.5-point underdogs or more away from home.

Betting the Moneyline: Michigan vs. Saint Louis

• This season, Michigan has won 31 out of the 34 games, or 91.2%, in which it has been the moneyline favorite.
• The Wolverines have a record of 20-1, a 95.2% win rate, when favored by -952 or more by oddsmakers this season.
• The bookmakers' moneyline implies a 90.5% chance of a victory for Michigan.
• Saint Louis has won in each of the two contests it has played as moneyline underdogs this season.
• Oddsmakers have given the Billikens the worst odds of winning they have seen this season with a +602 moneyline listed for this contest.
• Saint Louis has an implied victory probability of 14.2% according to the moneyline set for this matchup.