Louisville vs. Toledo Dunkel NCAA Football Picks, Predictions and Odds - Boca Raton Bowl

The Boca Raton Bowl features a matchup between the Toledo Rockets (who are 6.5-point underdogs) and the Louisville Cardinals on December 23, 2025 at 2 p.m. ET on ESPN.

The Cardinals beat the Kentucky Wildcats, 41-0, in their most recent game.

The Rockets' most recent contest was against the Central Michigan Chippewas, and they won by a score of 21-3.

Louisville vs. Toledo Predictions

Ahead of the upcoming contest between the Louisville Cardinals and Toledo Rockets, computer-derived against-the-spread, over/under, and score predictions are below, per Dunkel Index.

• Pick ATS: Rockets (+ 6.5)
• Pick OU: Under (44.5)
  
• Prediction: Cardinals 21 - Rockets 18

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Louisville vs. Toledo Moneylines

Take a peek below at the most recent moneylines for the Cardinals-Rockets matchup.

• Louisville Moneyline: -258
• Toledo Moneyline: +209

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Louisville Betting Insights

• Louisville is 7-3 in games it was favored on the moneyline (winning 70% of those games).
• Louisville is 5-1 (winning 83.3% of its games) when playing as a moneyline favorite of -258 or shorter.
• The Cardinals 12 games this season have gone over this contest's total of 44.5 points seven times.
• The Cardinals have an average point total of 52.8 in their contests this year, 8.3 more points than this game's over/under.
• The Cardinals are the 51st-highest scoring team in college football this year. The Rockets have scored the 43rd-most points.

Toledo Betting Insights

• Toledo lost the only game it has played as the underdog this season.
• Toledo has played as an underdog of +209 or more once this season and lost that game.
• Toledo and its opponents have combined to score more than 44.5 points in seven of 12 games this season.
• Toledo's games this year have had a 48.2-point total on average, 3.7 more points than this matchup's over/under.

Watch Louisville vs. Toledo on Fubo.

Key Stats for Louisville vs. Toledo

• The Cardinals sport the 69th-ranked offense this season (388.8 yards per game), and they've been even better on defense, ranking 15th-best with only 300.3 yards allowed per game.
• Louisville is totaling 30.2 points per game on offense (45th in the FBS), and ranks 36th on defense with 21.1 points allowed per game.
• The Rockets have been keeping opposing offenses in check on defense, giving up only 248.7 total yards per game (second-best). On offense, they rank 29th by compiling 422.4 total yards per game.
• Toledo's defensive unit has been leading the charge for the team, as it ranks fourth-best in the FBS with 12.2 points allowed per contest. In terms of offense, it is generating 31.6 points per game, which ranks 38th.