Louisville vs. Memphis Dunkel Predictions & Vegas Odds - Dec. 13

The No. 11 Louisville Cardinals (8-1) host the Memphis Tigers (4-4) at KFC Yum! Center, tipping off at 3:30 p.m. ET on Saturday, December 13, 2025. The Cardinals are 15.5-point favorites in the game. The matchup has an over/under of 160.5 points.

Louisville is coming off of an 87-78 win against Indiana in its last outing on Saturday. Ryan Conwell's team-leading 21 points led Louisville in the victory. In its last outing on Saturday, Memphis secured a 78-71 win against Baylor. In Memphis' win, Zachary Davis led the way with 23 points (adding 13 rebounds and one assist).

Louisville vs. Memphis Odds and Game Time

• When: Saturday, December 13, 2025 at 3:30 p.m. ET
• Where: KFC Yum! Center in Louisville, Kentucky
• Spread favorite: Louisville -15.5
• Moneyline favorite: Louisville -1724
• Moneyline underdog: Memphis +936
• Over/Under: 160.5 points

How to watch Louisville vs. Memphis

• TV Channel: ESPN
• Live Stream: Fubo
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Louisville vs. Memphis

• Louisville and its opponents have combined to outscore Saturday's total of 160.5 points five times this season.
• This season, Memphis has played just one game with a combined score over 160.5 points.
• The Cardinals average 93.8 points per game against the Tigers' 76.0, amounting to 9.3 points over the game's point total of 160.5.
• The 141.7 points per game these two teams surrender to opponents combined this season are 18.8 less than the 160.5-point over/under in this contest.
• Louisville has seen a 161.3 average over/under in its games this season, 0.8 points more than the over/under in this contest.
• Memphis' games have an average over/under of 150.1 points this season, 10.4 points lower than the over/under for this matchup.

Betting the Spread: Louisville vs. Memphis

• Against the spread, Louisville is 6-3-0 this year.
• This season, the Cardinals have an against-the-spread record of 3-2 in their five games as a favorite of 15.5 points or more.
• Memphis has played eight games, with seven wins against the spread.
• Louisville is 4-2 against the spread, and 6-0 overall, at home this season.
• This year, as a 15.5-point favorite or more at home, Louisville is 3-2 ATS.

Betting the Moneyline: Louisville vs. Memphis

• Louisville has entered the game as moneyline favorites eight times this season and won seven of those games.
• The Cardinals have been at least a -1724 moneyline favorite four times this season and won each of those games.
• The oddsmakers' moneyline implies a 94.5% chance of a victory for Louisville.
• Memphis has come away with one win in the four contests it has been listed as the moneyline underdog this season.
• Oddsmakers have given the Tigers the worst odds of winning they have seen this season with a +936 moneyline listed for this contest.
• The moneyline set for this matchup implies Memphis has a 9.7% chance of coming away with a victory in the contest.