Chiefs vs. Colts Week 2 Dunkel NFL Picks, Predictions and Odds

The Kansas City Chiefs (1-0) are considered favorites (-6.5) according to the oddsmakers ahead of their game versus the Indianapolis Colts (0-1) on September 20, 2026, starting at 8:20 p.m. ET, airing on NBC/Peacock. The expected point total for the matchup is set at 46.5.

The Chiefs ranked 21st in scoring offense (21.3 points per game) and sixth in scoring defense (19.3 points allowed per game) last season. The Colts ranked ninth in total offense (345.9 yards per game) and 23rd in total defense (349.8 yards allowed per game) last year.

Chiefs vs. Colts Odds and Game Time

• Date: Sunday, September 20, 2026
• Time: 8:20 p.m. ET
• City: Kansas City, Missouri
• Venue: GEHA Field at Arrowhead Stadium
• Total: 46.5 points
• Spread: Chiefs -6.5
• Moneyline: Chiefs (-285), Colts (+230)

How to watch Chiefs vs. Colts

• TV Channel: NBC/Peacock

Betting the Over/Under: Chiefs vs. Colts

• The Chiefs and their opponents went over 46.5 combined points in six of 17 games last season.
• Last season, the combined scoring went over the point total four times in Chiefs games.
• The Colts combined with their opponents to score more than 46.5 points in 11 of 17 games last season.
• Last year, nine Indianapolis games went over the point total.
• The teams combined to score 48.7 points per game last season, 2.2 more points than this matchup's total.
• These teams allowed a combined 43.5 points per game last year, 3.0 fewer points than the total for this contest.

Betting the Spread: Chiefs vs. Colts

• Kansas City covered six times in 17 chances against the spread last season.
• Kansas City was favored by 6.5 points or more three times last season, and covered the spread in three of those games.
• The Colts won nine games against the spread last season, while failing to cover eight times.
• Indianapolis was an underdog by 6.5 points or more two times last season, and covered the spread in both.
• The Chiefs were 5-4 against the spread, and 5-4 overall, at home last season.
• At home last year, as 6.5-point favorites or more, Kansas City was unbeaten ATS (2-0).
• The Colts were 5-3 against the spread, and 2-6 overall, away from home last season.
• On the road, Indianapolis was unbeaten ATS (2-0) as 6.5-point underdogs or more.

Betting the Moneyline: Chiefs vs. Colts

• Kansas City won five of the 14 games it was favored on the moneyline last season (35.7%).
• The Colts were underdogs eight times last season and won twice.
• Kansas City won all three games it played as a moneyline favorite with odds of -285 or shorter.
• Last season, Indianapolis was at least a +230 underdog on the moneyline two times, losing each of those contests.
• The implied moneyline probability for this matchup gives the Chiefs a 74.0% chance to win.

Dunkel Prediction for Chiefs vs. Colts

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