Iowa State vs. Tennessee Dunkel Predictions & Vegas Odds - Sweet 16

A Sweet 16 NCAA Tournament matchup between the No. 2 Iowa State Cyclones (29-7) and No. 6 Tennessee Volunteers (24-11) will determine one of the squads heading to the Midwest Region bracket final when it tips off on Friday at United Center, tipping off at 10:25 p.m. ET, airing on TBS. Bookmakers think Iowa State will claim victory in this one, naming the as 3.5-point favorites. The point total is set at 139.5 in the matchup.

Iowa State came out on top in its last outing 82-63 against Kentucky on Sunday. In the victory, Tamin Lipsey paced Iowa State with 26 points. Tennessee is coming off of a 79-72 win against Virginia in its most recent game on Sunday. Ja'Kobi Gillespie recorded 21 points, three rebounds and six assists for Tennessee.

Iowa State vs. Tennessee Odds and Game Time

• When: Friday, March 27, 2026 at 10:25 p.m. ET
• Where: United Center in Chicago, Illinois
• Spread favorite: Iowa State -3.5
• Moneyline favorite: Iowa State -182
• Moneyline underdog: Tennessee +146
• Over/Under: 139.5 points

How to watch Iowa State vs. Tennessee

• TV Channel: TBS
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Iowa State vs. Tennessee

• Iowa State and its opponents have combined to outscore Friday's over/under of 139.5 points 22 times this season.
• In Tennessee's 35 games this season, 26 finished with more combined points than Friday's over/under of 139.5.
• The Cyclones average 82.5 points per game against the Volunteers' 79.4, amounting to 22.4 points over the matchup's total of 139.5.
• This matchup's over/under is 5.1 fewer points than the 134.4 these two teams combine to give up per game in 2024.
• Iowa State has seen a 147.9 average over/under in its games this season, 8.4 points more than the over/under in this contest.
• Tennessee's games have an average over/under of 148.5 points this season, nine more points than the over/under for this matchup.

Betting the Spread: Iowa State vs. Tennessee

• Iowa State is 22-14-0 against the spread this season.
• The Cyclones are 19-11 ATS when favored by 3.5 points or more this season.
• Tennessee has played 35 games, with 16 wins against the spread.
• The Volunteers have been underdogs by 3.5 points or more four times this year and are 3-1 ATS in those matchups.
• At home this year, Iowa State is 9-8 against the spread and 16-1 overall.
• At home, as a 3.5-point favorite or more, Iowa State is 8-8 ATS.
• This year in away games, Tennessee is 4-6 against the spread and 5-5 overall.
• Away from home, Tennessee has two wins ATS (2-2) as 3.5-point underdogs or more.

Betting the Moneyline: Iowa State vs. Tennessee

• Iowa State has entered the game as moneyline favorites 31 times this season and won 26, or 83.9%, of those games.
• The Cyclones have entered 27 games this season favored by -182 or more and are 24-3 in those contests.
• Bookmakers have implied with the moneyline set for this matchup that Iowa State has a 64.5% chance to win.
• Tennessee has come away with three wins in the six contests it has been listed as the moneyline underdog this season.
• The Volunteers have been listed as an underdog of +146 or more on two occasions this season and split those games.
• The moneyline set for this matchup implies Tennessee has a 40.7% chance of walking away with the win.