Iowa State vs. Southern Miss Dunkel Predictions & Vegas Odds - Nov. 6

The No. 18 Iowa State Cyclones (0-1) host the Southern Miss Golden Eagles (1-0) at James H. Hilton Coliseum, starting at 8 p.m. ET on Friday, November 6, 2026. The Golden Eagles are 30.5-point underdogs in the game. The matchup has an over/under set at 150.5 points.

Iowa State is coming off of an 80-76 loss to Memphis in its last outing on Monday. Ryan Prather Jr. scored a team-best 19 points for Iowa State in the loss. Southern Miss' most recent contest on Monday ended in an 82-35 win against Tougaloo. Isaac Tavares totaled 12 points, nine rebounds and two assists for Southern Miss.

Iowa State vs. Southern Miss Odds and Game Time

• When: Friday, November 6, 2026 at 8 p.m. ET
• Where: James H. Hilton Coliseum in Ames, Iowa
• Spread favorite: Iowa State -30.5
• Moneyline favorite: Iowa State -100000
• Moneyline underdog: Southern Miss +5000
• Over/Under: 150.5 points

How to watch Iowa State vs. Southern Miss

• TV Channel: ESPN+
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Iowa State vs. Southern Miss

• Iowa State and its opponent combined to score over 150.5 points, the current matchup's point total, in 15 of 37 games last season.
• Southern Miss played 17 games last season (51.5% of opportunities) in which the teams combined to score more than 150.5 points.
• The two teams averaged a combined 6.2 more points per game (156.7) a season ago than this matchup's total of 150.5 points.
• Opponents of these teams averaged a combined 139.5 points per game last season, 11.0 fewer than the point total for this matchup.
• The average point total for Iowa State's games last year was 2.9 fewer points than the over/under of 150.5 in this matchup.
• The average over/under in Southern Miss' games in 2025 was 1.9 fewer points than the point total of 150.5 for this game.

Betting the Spread: Iowa State vs. Southern Miss

• Iowa State put together a 22-15-0 record against the spread last season.
• The Cyclones were 3-4 ATS last season when playing as at least 30.5-point favorites.
• Southern Miss went 17-16-0 ATS last season.
• Iowa State was 9-8 against the spread, and 16-1 overall, at home last season.
• At home last season, Iowa State was 3-4 ATS as a 30.5-point favorite or greater.
• Away from home last season, Southern Miss was 7-8 against the spread and 4-11 overall.

Betting the Moneyline: Iowa State vs. Southern Miss

• Iowa State was favored on the moneyline 32 total times last season. It finished 26-6 in those games.
• The Cyclones won all three games they played as a moneyline favorite with odds of -100000 or shorter.
• The implied moneyline probability in this matchup gives Iowa State a 99.9% chance to win.
• Last season, Southern Miss won nine out of the 24 games, or 37.5%, in which it was the underdog.
• The Golden Eagles were not a bigger underdog last season than the +5000 moneyline set for this game.
• Southern Miss has a 2.0% chance to win this game based on the implied probability of the moneyline.