Iowa State vs. Kentucky Dunkel Predictions & Vegas Odds - Second Round

The No. 2 seed Iowa State Cyclones (28-7) will take to the court against the No. 7 seed Kentucky Wildcats (22-13) on Sunday with a spot in the Sweet 16 of the NCAA Tournament up for grabs. Iowa State is a 4.5-point favorite to take a step forward in the bracket, which tips off at 2:45 p.m. ET on CBS. The over/under is set at 146.5 for the matchup.

Their last time out, Iowa State won on Friday 108-74 against Tennessee State. Killyan Toure totaled 25 points, 11 rebounds and six assists for Iowa State. Kentucky's last game on Friday ended in an 89-84 victory against Santa Clara in overtime. Otega Oweh put up 35 points, eight rebounds and seven assists for Kentucky.

Iowa State vs. Kentucky Odds and Game Time

• When: Sunday, March 22, 2026 at 2:45 p.m. ET
• Where: Enterprise Center in St. Louis, Missouri
• Spread favorite: Iowa State -4.5
• Moneyline favorite: Iowa State -237
• Moneyline underdog: Kentucky +190
• Over/Under: 146.5 points

How to watch Iowa State vs. Kentucky

• TV Channel: CBS
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Iowa State vs. Kentucky

• Iowa State and its opponents have combined to outscore Sunday's over/under of 146.5 points 19 times this season.
• A total of 24 of Kentucky's games have ended with a combined score higher than 146.5 points this season.
• Together, the two teams combine for 163.5 points per game, 17 points more than the point total of 146.5 for this game.
• These two teams surrender a combined 139.5 points per game, seven less than this contest's over/under.
• On average, Iowa State has had a 147.9-point over/under in its games this season, 1.4 more points than the over/under in this matchup.
• A difference of 8.6 points separates the average over/under in Kentucky's games (155.1 points) and this contest's over/under (146.5).

Betting the Spread: Iowa State vs. Kentucky

• In Iowa State's 35 games this year, it has 21 wins against the spread.
• The Cyclones are 18-10 ATS when favored by 4.5 points or more this season.
• Kentucky is 18-17-0 against the spread this season.
• This season, the Wildcats have an ATS record of 4-5 in their nine games as an underdog of 4.5 points or more.
• At home this year, Iowa State is 9-8 against the spread and 16-1 overall.
• At home, Iowa State is 8-8 ATS as a 4.5-point favorite or greater.
• This year in away games, Kentucky is 5-5 against the spread and 4-6 overall.
• Kentucky is unbeaten ATS (1-0) away from home as 4.5-point underdogs or more.

Betting the Moneyline: Iowa State vs. Kentucky

• This season, Iowa State has been moneyline favorites 30 times and won 25, or 83.3%, of those games.
• The Cyclones have a record of 22-3 in games where oddsmakers favor them by at least -237 on the moneyline.
• Iowa State has a 70.3% chance to win this game based on the implied probability of the moneyline.
• Kentucky has won in two, or 18.2%, of the 11 contests it has been named as the moneyline underdog this year.
• This season, the Wildcats have been victorious two times in seven chances when named as an underdog of at least +190 or longer on the moneyline.
• Kentucky has an implied victory probability of 34.5% according to the moneyline set by oddsmakers for this matchup.