Duke vs. Siena Dunkel Predictions & Vegas Odds - First Round

The No. 1 seed Duke Blue Devils (32-2) are a 28.5-point favorite in the opening round of the NCAA Tournament against the No. 16 seed Siena Saints (23-11) on Thursday at Bon Secours Wellness Arena. The matchup begins at 2:50 p.m. ET on CBS. Here are insights into this East Region 1-16 matchup to help you fill out your bracket. The matchup's over/under is set at 135.5.

In its last time out, Duke won on Saturday 74-70 against Virginia. Isaiah Evans put up 20 points, two rebounds and one assist for Duke. Siena heads into this game on the heels of a 64-54 victory over Merrimack on Tuesday. Gavin Doty's team-high 23 points paced Siena in the victory.

Duke vs. Siena Odds and Game Time

• When: Thursday, March 19, 2026 at 2:50 p.m. ET
• Where: Bon Secours Wellness Arena in Greenville, South Carolina
• Spread favorite: Duke -28.5
• Moneyline favorite: Duke -25000
• Moneyline underdog: Siena +4340
• Over/Under: 135.5 points

How to watch Duke vs. Siena

• TV Channel: CBS
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Duke vs. Siena

• This season, Duke and its opponents have combined to outscore Thursday's over/under of 135.5 points 21 times.
• This season, 19 of Siena's games have ended with a combined score higher than 135.5 points.
• Together, the two teams combine for 152.8 points per game, 17.3 points more than the point total of 135.5 for this game.
• The 128.8 points per game these two teams allow to opponents combined this season are 6.7 less than the 135.5-point total in this contest.
• Duke has a 145.4 average over/under in its games this season, 9.9 more points than the over/under in this contest.
• The over/under for this contest is 0.7 points lower than the average over/under in Siena's games this season of 136.2.

Betting the Spread: Duke vs. Siena

• Against the spread, Duke is 19-15-0 this year.
• The Blue Devils have been favored by 28.5 points or more six times this season and are 3-3 ATS in those matchups.
• Siena is 20-14-0 against the spread this season.
• At home this season, Duke is 15-0 overall and 7-8 against the spread.
• At home, as a 28.5-point favorite or greater, Duke has two wins ATS (2-3).
• Siena is 9-7 against the spread, and 9-7 overall, on the road.

Betting the Moneyline: Duke vs. Siena

• This season, Duke has been moneyline favorites 30 times and won 28, or 93.3%, of those games.
• The Blue Devils have played as a favorite of -25000 or more once this season and won that game.
• Duke has a 99.6% chance to win this game based on the implied probability of the moneyline.
• Siena has won in two of the six contests it has been named as the moneyline underdog this year.
• This is the worst odds of a win that sportsbooks have given the Saints this season with a +4340 moneyline set for this game.
• Bookmakers have implied with the moneyline set for this matchup that Siena has a 2.3% chance of pulling out a win.