Guardians vs. Royals Dunkel MLB Picks, Predictions and Prop Bets - Sept. 25

The Cleveland Guardians visit the Kansas City Royals to open a three-game series at Kauffman Stadium, with first pitch at 7:40 p.m. ET on Friday. Gavin Williams (14-8, 3.63 ERA) gets the start for the Guardians, who are 83-76 this season and first in the AL Central. Noah Cameron (9-8, 3.92 ERA) is expected to start for the Royals, who are 68-91 and fifth in the AL Central.

Despite playing away from their home ballpark, the Guardians are favored to win (-142) over the Royals (+117). The over/under for the Guardians-Royals game is 7.

Guardians vs. Royals Odds, Game Time

• Game day: Friday, September 25, 2026
• Game time: 7:40 p.m. ET
• Location: Kansas City, Missouri
• Stadium: Kauffman Stadium
• Favorite: Guardians (-142)
• Underdog: Royals (+117)
• Over/under: 7

How to Watch Guardians vs. Royals

• TV Channel: ROYL and CLEG
• Live Stream: Fubo (Watch for free)

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Guardians vs. Royals: Betting the Moneyline

• The Guardians have won 53 of the 98 games they were the moneyline favorite this season (54.1%).
• Kansas City has been pegged as an underdog in 105 games this year and has walked away with the win 41 times (39%) in those games.
• Cleveland has entered 38 games this season favored by -142 or more and is 26-12 in those contests.
• This year, the Royals have won 18 of 50 games when listed as at least +117 or worse on the moneyline.
• Based on this game's moneyline, the Guardians have an implied win probability of 58.7%.
• The Royals have an implied victory probability of 46.1% according to the moneyline set for this matchup.

Guardians vs. Royals: Betting the Spread & Total

• The Guardians have combined with opponents to go over the total 75 times this season for a 75-82-2 record against the over/under.
• So far this season, Kansas City and its opponents have hit the over in 71 of its 159 games with a total.
• The Guardians have put together a 77-82-0 record against the spread this season (covering 48.4% of the time).
• The Royals have posted a record of 76-83-0 against the spread this season.