Guardians vs. White Sox Dunkel MLB Picks, Predictions and Prop Bets - Sept. 16

Travis Bazzana leads the Cleveland Guardians into a matchup with the Chicago White Sox a game after homering twice in a 7-6 victory over the White Sox. It begins at 1:10 p.m. ET on Wednesday. Parker Messick (11-9, 2.51 ERA) gets the start for the Guardians, who are 77-75 this season and second in the AL Central. Anthony Kay (9-9, 4.59 ERA) is starting for the White Sox, who are 77-74 and first in the AL Central.

The White Sox (+133) take their show on the road to face the favored Guardians (-163). The game has an over/under set at 7 runs.

Guardians vs. White Sox Odds, Game Time

• Game day: Wednesday, September 16, 2026
• Game time: 1:10 p.m. ET
• Location: Cleveland, Ohio
• Stadium: Progressive Field
• Favorite: Guardians (-163)
• Underdog: White Sox (+133)
• Over/under: 7

How to Watch Guardians vs. White Sox

• TV Channel: ESPN
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Guardians vs. White Sox: Betting the Moneyline

• The Guardians have won 49 of the 94 games they were the moneyline favorite this season (52.1%).
• Chicago has come away with 53 wins in the 107 contests it has been listed as the underdogs in this season.
• Cleveland has a record of 10-6, a 62.5% win rate, when favored by -163 or more by bookmakers this season.
• This season, the White Sox have been victorious 10 times in 28 chances when named as an underdog of at least +133 or longer on the moneyline.
• The implied moneyline probablility in this matchup gives the Guardians a 62% chance to win.
• The White Sox have an implied victory probability of 42.9% according to the moneyline set by sportsbooks for this matchup.

Guardians vs. White Sox: Betting the Spread & Total

• The Guardians have played in 152 games with an over/under set, and have combined with their opponents to go over the total 73 times (73-78-1).
• Chicago and its opponents have gone over the total this season in 86 of its 151 opportunities.
• The Guardians have gone 71-81-0 against the spread this season.
• The White Sox have an against the spread record of 86-65-0 in 151 games with a line this season.