Guardians vs. White Sox Dunkel MLB Picks, Predictions and Prop Bets - Sept. 15

The Cleveland Guardians and Chicago White Sox meet on Tuesday at 6:40 p.m. ET, at Progressive Field. Foster Griffin (15-5, 3.65 ERA) will start for the Guardians, who are 76-75 this season and second in the AL Central. Davis Martin (9-7, 4.05 ERA) is expected to start for the White Sox, who are 77-73 and first in the AL Central.

The Guardians are moderate favorites on the moneyline (-152) at home over the White Sox (+124). The total for this contest is set at 8.5.

Guardians vs. White Sox Odds, Game Time

• Game day: Tuesday, September 15, 2026
• Game time: 6:40 p.m. ET
• Location: Cleveland, Ohio
• Stadium: Progressive Field
• Favorite: Guardians (-152)
• Underdog: White Sox (+124)
• Over/under: 8.5

How to Watch Guardians vs. White Sox

• TV Channel: CLEG and CHSN
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Guardians vs. White Sox: Betting the Moneyline

• The Guardians have compiled a 48-45 record in games they were listed as the moneyline favorite (winning 51.6% of those games).
• Chicago has been underdogs in 106 games this season and has come away with the win 53 times (50%) in those contests.
• This season Cleveland has won 17 of its 26 games, or 65.4%, when favored by at least -152 on the moneyline.
• This year, the White Sox have won 20 of 46 games when listed as at least +124 or worse on the moneyline.
• The Guardians have an implied moneyline win probability of 60.3% in this game.
• The White Sox have an implied victory probability of 44.6% according to the moneyline set by sportsbooks for this matchup.

Guardians vs. White Sox: Betting the Spread & Total

• The Guardians have played in 151 games with an over/under set, and have combined with their opponents to go over the total 72 times (72-78-1).
• Chicago and its opponents have hit the over in 85 of its 150 games with a total this season.
• The Guardians have a 71-80-0 record ATS this season.
• The White Sox have an against the spread mark of 85-65-0 in 150 games with a line this season.