Guardians vs. White Sox Dunkel MLB Picks, Predictions and Prop Bets - June 23

The Chicago White Sox host the Cleveland Guardians at 7:40 p.m. ET on Tuesday. Parker Messick (7-3, 2.70 ERA) will start for the Guardians, who are 41-38 this season and second in the AL Central. Sean Burke (4-4, 3.89 ERA) is the expected starter for the White Sox, who are 40-37 and first in the AL Central.

Per the moneyline, the matchup between the Guardians (-116) and White Sox (-106) looks like a close one. The over/under for the Guardians-White Sox game is set at 7.

Guardians vs. White Sox Odds, Game Time

• Game day: Tuesday, June 23, 2026
• Game time: 7:40 p.m. ET
• Location: Chicago, Illinois
• Stadium: Rate Field
• Favorite: Guardians (-116)
• Underdog: White Sox (-106)
• Over/under: 7

How to Watch Guardians vs. White Sox

• TV Channel: CHSN and CLEG
• Live Stream: Fubo (Watch for free)

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Guardians vs. White Sox: Betting the Moneyline

• The Guardians have been the moneyline favorite 41 total times this season. They've finished 21-20 in those games.
• Chicago has come away with 32 wins in the 65 contests it has been listed as the underdogs in this season.
• Cleveland is 21-19 this season when entering a game favored by -116 or more on the moneyline.
• The White Sox have a win-loss record of 29-31 when favored by -106 or worse by sportsbooks this year.
• The implied moneyline probablility for this matchup gives the Guardians a 53.7% chance to win.
• The moneyline set for this matchup implies the White Sox have a 51.5% chance of coming away with a victory in the contest.

Guardians vs. White Sox: Betting the Spread & Total

• The Guardians have played in 79 games with an over/under set, and have combined with their opponents to go over the total 39 times (39-40-0).
• Chicago's games have gone over the total in 46 of its 77 chances.
• The Guardians are 41-38-0 against the spread this season.
• In 77 games with a line this season, the White Sox have a mark of 44-33-0 against the spread.