Guardians vs. White Sox Dunkel MLB Picks, Predictions and Prop Bets - June 22

The Chicago White Sox will aim to stop a three-game losing streak when hosting the Cleveland Guardians at 7:40 p.m. ET on Monday. Gavin Williams (9-4, 3.83 ERA) gets the start for the Guardians, who are 41-37 this season and first in the AL Central. Anthony Kay (6-2, 4.61 ERA) is the expected starter for the White Sox, who are 39-37 and second in the AL Central.

Oddsmakers expect a close matchup between the Guardians (-112 to win) and the White Sox (-109). The over/under for the Guardians-White Sox game is set at 7.5.

Guardians vs. White Sox Odds, Game Time

• Game day: Monday, June 22, 2026
• Game time: 7:40 p.m. ET
• Location: Chicago, Illinois
• Stadium: Rate Field
• Favorite: Guardians (-112)
• Underdog: White Sox (-109)
• Over/under: 7.5

How to Watch Guardians vs. White Sox

• TV Channel: CHSN and CLEG
• Live Stream: Fubo (Watch for free)

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Guardians vs. White Sox: Betting the Moneyline

• The Guardians are 21-19 in games they were listed as the moneyline favorite (winning 52.5% of those games).
• Chicago has been pegged as an underdog in 64 games this year and has walked away with the win 31 times (48.4%) in those games.
• Cleveland has entered 40 games this season favored by -112 or more and is 21-19 in those contests.
• This season, the White Sox have come away with a win 30 times in 63 chances when named as an underdog of at least -109 or longer on the moneyline.
• The implied moneyline probablility for this matchup gives the Guardians a 52.8% chance to win.
• The moneyline set for this matchup implies the White Sox have a 52.2% chance of walking away with the win.

Guardians vs. White Sox: Betting the Spread & Total

• The Guardians have combined with opponents to hit the over on the total 38 times this season for a 38-40-0 record against the over/under.
• Chicago and its opponents have hit the over in 45 of its 76 games with a total this season.
• The Guardians have collected a 41-37-0 record ATS this season (covering 52.6% of the time).
• In 76 games with a line this season, the White Sox have a mark of 43-33-0 against the spread.