Guardians vs. Athletics Dunkel MLB Picks, Predictions and Prop Bets - Sept. 18

The Athletics hope to break their three-game losing run versus the Cleveland Guardians, at 7:10 p.m. ET on Friday. Daniel Espino (0-0, 2.92 ERA) gets the start for the Guardians, who are 78-75 this season and second in the AL Central. Mason Barnett (1-4, 7.08 ERA) is the expected starter for the Athletics, who are 61-92 and fourth in the AL West.

The Guardians are moderate favorites on the moneyline (-222) at home over the Athletics (+179). The total for the Guardians-Athletics game is set at 8.5.

Guardians vs. Athletics Odds, Game Time

• Game day: Friday, September 18, 2026
• Game time: 7:10 p.m. ET
• Location: Cleveland, Ohio
• Stadium: Progressive Field
• Favorite: Guardians (-222)
• Underdog: Athletics (+179)
• Over/under: 8.5

How to Watch Guardians vs. Athletics

• TV Channel: CLEG and NBCS-CA
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Guardians vs. Athletics: Betting the Moneyline

• The Guardians have compiled a 50-45 record in games they were favored on the moneyline (winning 52.6% of those games).
• The Athletics have been chosen as underdogs in 117 games this year and have walked away with the win 45 times (38.5%) in those games.
• The Guardians have played as a favorite of -222 or more once this season and lost that game.
• This season, the Athletics have come away with a win five times in 13 chances when named as an underdog of at least +179 or worse on the moneyline.
• The implied moneyline probablility in this matchup gives the Guardians a 68.9% chance to win.
• Bookmakers have implied with the moneyline set for this matchup that the Athletics have a 35.8% chance of pulling out a win.

Guardians vs. Athletics: Betting the Spread & Total

• The Guardians have combined with their opponents to hit the over on the total 74 times this season for a 74-78-1 record against the over/under.
• Games involving the Athletics have gone over the total set by sportsbooks in 78 of 153 chances this season.
• The Guardians have put together a 72-81-0 record against the spread this season (covering 47.1% of the time).
• The Athletics are 73-80-0 against the spread in their 153 games that had a posted line this season.