White Sox vs. Nationals Dunkel MLB Picks, Predictions and Prop Bets - April 25

The Washington Nationals carry a three-game losing streak into a home contest versus the Chicago White Sox, at 4:10 p.m. ET on Saturday. Noah Schultz (1-1, 3.86 ERA) gets the start for the White Sox, who are 11-15 this season and fourth in the AL Central. Jake Irvin (1-3, 6.00 ERA) is the expected starter for the Nationals, who are 11-16 and third in the NL East.

At home, the White Sox are favored to win on the moneyline (-141) over the Nationals (+119). The total for the White Sox-Nationals game is set at 8.

White Sox vs. Nationals Odds, Game Time

• Game day: Saturday, April 25, 2026
• Game time: 4:10 p.m. ET
• Location: Chicago, Illinois
• Stadium: Rate Field
• Favorite: White Sox (-141)
• Underdog: Nationals (+119)
• Over/under: 8

How to Watch White Sox vs. Nationals

• TV Channel: CHSN and NATS
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

White Sox vs. Nationals: Betting the Moneyline

• The White Sox have been the moneyline favorite only one other time so far this season, a game they won.
• Washington has been pegged as an underdog in 26 games this year and has walked away with the win 11 times (42.3%) in those games.
• Chicago has not been bigger favorites this season than the -141 moneyline set for this game.
• The Nationals have a mark of 10-11 in contests where sportsbooks favor them by +119 or worse on the moneyline.
• The implied moneyline probablility for this matchup gives the White Sox a 58.5% chance to win.
• The moneyline set for this matchup implies the Nationals have a 45.7% chance of walking away with the win.

White Sox vs. Nationals: Betting the Spread & Total

• In the 26 games in which oddsmakers have set an over/under for the White Sox, they have combined with opponents to go over the total 16 times (16-10-0).
• Games involving Washington have gone over the total set by oddsmakers in 18 of 27 chances this season.
• The White Sox have put together a 12-14-0 record against the spread this season (covering 46.2% of the time).
• The Nationals have posted a record of 16-11-0 against the spread this season.