Cubs vs. Padres Dunkel MLB Picks, Predictions and Prop Bets - April 28

The San Diego Padres will look to Luis Campusano, currently on a two-game homer streak, against the Chicago Cubs at 9:40 p.m. ET on Tuesday, at Petco Park. Edward Cabrera (2-0, 2.73 ERA) gets the start for the Cubs, who are 17-12 this season and second in the NL Central. Walker Buehler (1-2, 5.75 ERA) is expected to start for the Padres, who are 19-9 and second in the NL West.

The moneyline odds for the Cubs (-117) versus the Padres (-102) indicate a tight game. The contest has an over/under set at 8.

Cubs vs. Padres Odds, Game Time

• Game day: Tuesday, April 28, 2026
• Game time: 9:40 p.m. ET
• Location: San Diego, California
• Stadium: Petco Park
• Favorite: Cubs (-117)
• Underdog: Padres (-102)
• Over/under: 8

How to Watch Cubs vs. Padres

• TV Channel: SDPA and MARQ
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Cubs vs. Padres: Betting the Moneyline

• The Cubs have put together an 11-7 record in games they were listed as the moneyline favorite (winning 61.1% of those games).
• San Diego has been underdogs in 11 games this season and has come away with the win six times (54.5%) in those contests.
• Chicago has a record of 9-7, a 56.2% win rate, when favored by -117 or more by sportsbooks this season.
• This season, the Padres have come away with a win five times in 10 chances when named as an underdog of at least -102 or worse on the moneyline.
• Based on this matchup's moneyline, the Cubs' implied win probability is 53.9%.
• Bookmakers have implied with the moneyline set for this matchup that the Padres have a 50.5% chance of pulling out a win.

Cubs vs. Padres: Betting the Spread & Total

• The Cubs have had an over/under set by bookmakers 29 times, and have combined with opponents to go over the total in 18 of those games (18-9-2).
• San Diego and its opponents have gone over the total this season in 12 of its 28 opportunities.
• The Cubs are 14-15-0 ATS this season.
• The Padres are 18-10-0 against the spread in their 28 games that had a posted line this season.