Cubs vs. Reds Dunkel MLB Picks, Predictions and Prop Bets - Sept. 18

The Chicago Cubs visit the Cincinnati Reds to start a three-game series at Great American Ball Park, with first pitch at 6:40 p.m. ET on Friday. Clay Holmes (6-7, 2.85 ERA) will start for the Cubs, who are 85-68 this season and second in the NL Central. Chase Burns (15-3, 2.80 ERA) is expected to start for the Reds, who are 71-82 and fifth in the NL Central.

Despite playing away from their home ballpark, the Cubs are favored to win (-140) over the Reds (+116). The game has an over/under set at 8.5 runs.

Cubs vs. Reds Odds, Game Time

• Game day: Friday, September 18, 2026
• Game time: 6:40 p.m. ET
• Location: Cincinnati, Ohio
• Stadium: Great American Ball Park
• Favorite: Cubs (-140)
• Underdog: Reds (+116)
• Over/under: 8.5

How to Watch Cubs vs. Reds

• TV Channel: CINR and MARQ
• Live Stream: Fubo (Watch for free)

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Cubs vs. Reds: Betting the Moneyline

• The Cubs have been favored on the moneyline 106 total times this season. They've finished 60-46 in those games.
• Cincinnati has come away with 48 wins in the 111 contests it has been listed as the underdogs in this season.
• Chicago has entered 61 games this season favored by -140 or more and is 35-26 in those contests.
• This year, the Reds have won 23 of 58 games when listed as at least +116 or worse on the moneyline.
• Based on this game's moneyline, the Cubs have an implied win probability of 58.3%.
• The moneyline set for this matchup implies the Reds have a 46.3% chance of coming away with a victory in the contest.

Cubs vs. Reds: Betting the Spread & Total

• The Cubs have played in 153 games with set over/under, and have combined with opponents to go over the total 85 times (85-63-5).
• Cincinnati and its opponents have hit the over in 80 of its 153 games with a total this season.
• The Cubs have gone 72-81-0 ATS this season.
• The Reds have an against the spread record of 77-76-0 in 153 games with a line this season.