Bills vs. Lions Week 2 Dunkel NFL Picks, Predictions and Odds

The Buffalo Bills (1-0) are considered favorites (-4.5) according to the point spread ahead of their game versus the Detroit Lions (1-0) on September 17, 2026, starting at 8:15 p.m. ET, airing on Amazon Prime Video. The expected point total for the matchup is 54.5.

On offense, the Bills were a top-five unit last season, ranking fourth-best in the NFL by putting up 376.3 yards per game. They ranked seventh on defense (293.1 yards allowed per game). On the offensive side of the ball, the Lions were a top-five unit last season, ranking fifth-best in the NFL by compiling 373.2 yards per game. They ranked 18th on defense (331.9 yards allowed per game).

Bills vs. Lions Odds and Game Time

• Date: Thursday, September 17, 2026
• Time: 8:15 p.m. ET
• City: Orchard Park, New York
• Venue: New Highmark Stadium
• Total: 54.5 points
• Spread: Bills -4.5
• Moneyline: Bills (-218), Lions (+180)

How to watch Bills vs. Lions

• TV Channel: Amazon Prime Video

Betting the Over/Under: Bills vs. Lions

• The Bills' 17 games last season went over this contest's total of 54.5 points four times.
• Last season, the combined scoring went over the point total nine times in Bills games.
• Detroit played eight games last season that finished with a combined score over 54.5 points.
• Last season, 10 Detroit games went over the point total.
• The two teams combined to score 56.6 points per game last season, 2.1 more points than this matchup's total.
• These teams gave up a combined 45.8 points per game last year, 8.7 fewer points than the over/under for this contest.

Betting the Spread: Bills vs. Lions

• Buffalo went 8-9-0 ATS last season.
• Buffalo was favored by 4.5 points or more 12 times last season, and covered the spread in four of those games.
• The Lions put together an 8-9-0 record against the spread last season.
• Detroit covered the spread once last year (1-1 ATS) when playing as at least 4.5-point underdogs.
• At home last season, the Bills were 7-2 overall and 4-5 against the spread.
• At home last season, Buffalo had two wins ATS (2-4) as 4.5-point favorites or greater.
• The Lions were 4-5 against the spread, and 4-5 overall, in away games last season.
• Detroit had one win ATS (1-1) as 4.5-point underdogs or more away from home.

Betting the Moneyline: Bills vs. Lions

• Buffalo won 66.7% of the games last season when it was favored on the moneyline (10-5).
• The Lions were underdogs in six games last season and won two (33.3%) of those contests.
• Buffalo finished 8-3 last year (winning 72.7% of its games) when it played as a moneyline favorite of -218 or shorter.
• Last season, Detroit won one of its two games when it was the underdog by at least +180 on the moneyline.
• Based on this contest's moneyline, the Bills have an implied win probability of 68.6%.

Dunkel Prediction for Bills vs. Lions

For more expert NFL picks, visit our Dunkel Index NFL Picks and Predictions.