Bills vs. Browns Week 16 Dunkel NFL Picks, Predictions and Odds

The Buffalo Bills (10-4) will be attempting to continue a three-game winning run against the Cleveland Browns (3-11). The Bills are heavy favorites (-10.5). The expected point total for the matchup is set at 41.5.

On the offensive side of the ball, the Bills have been a top-five unit, ranking fourth-best in the NFL by putting up 29.4 points per game. They rank 16th on defense (23.1 points allowed per game). The Browns have been struggling on offense, ranking fourth-worst in the NFL with 16.1 points per game. They have been more productive on the other side of the ball, giving up 23.7 points per contest (19th-ranked).

Bills vs. Browns Odds and Game Time

• Date: Sunday, December 21, 2025
• Time: 1 p.m. ET
• City: Cleveland, Ohio
• Venue: Huntington Bank Field
• Total: 41.5 points
• Spread: Bills -10.5
• Moneyline: Bills (-649), Browns (+470)

How to watch Bills vs. Browns

• TV Channel: CBS (KBAK-Bakersfield, CA)
• Live Stream: Fubo

Betting the Over/Under: Bills vs. Browns

• In 11 of 14 games this season, the Bills and their opponents have combined to score more than 41.5 points.
• Buffalo and its opponent have combined to go over the point total seven out of 14 times this season.
• The Browns have played five games this season that finished with a combined score over 41.5 points.
• So far this year, seven of Cleveland's 14 games with a set number have gone over the point total.
• The two teams average 45.5 points per game combined, four more points than this game's total.
• Opponents of these two teams average 46.8 combined points per game, 5.3 more points than this matchup's total.

Betting the Spread: Bills vs. Browns

• Buffalo has covered the spread seven times in 14 games this season.
• Buffalo has not covered the spread when favored by 10.5 points or more this season (in two opportunities).
• The Browns have covered five times in 14 chances against the spread this season.
• Cleveland has not covered the spread when an underdog by 10.5 points or more this year (in one opportunity).
• The Browns are 4-3 against the spread, and 2-5 overall, at home.
• This season away from home, the Bills are 4-3 against the spread and 4-3 overall.

Betting the Moneyline: Bills vs. Browns

• Buffalo has an 8-4 record in games they were listed as the moneyline favorite (winning 66.7% of those games).
• This season, the Browns have been the underdog 11 times and won two of those games.
• Buffalo has played as a moneyline favorite of -649 or shorter in only two games this season, and it won both.
• Cleveland has played as an underdog of +470 or more once this season and lost that game.
• The Bills have an implied moneyline win probability of 86.6% in this game.

Dunkel Prediction for Bills vs. Browns

For more expert NFL picks, visit our Dunkel Index NFL Picks and Predictions.