Diamondbacks vs. Padres Dunkel MLB Picks, Predictions and Prop Bets - April 25

The Arizona Diamondbacks will look to Ildemaro Vargas, currently on an 18-game hitting streak, versus the San Diego Padres at 6:05 p.m. ET on Saturday, at Estadio Alfredo Harp Helu. Zac Gallen (1-1, 3.51 ERA) will start for the Diamondbacks, who are 14-11 this season and third in the NL West. German Marquez (2-1, 3.86 ERA) is expected to start for the Padres, who are 17-8 and first in the NL West.

The moneyline odds for the Diamondbacks (-119) versus the Padres (-101) indicate a tight game. The game's over/under is set at 16.

Diamondbacks vs. Padres Odds, Game Time

• Game day: Saturday, April 25, 2026
• Game time: 6:05 p.m. ET
• Location: Mexico City, Mexico
• Stadium: Estadio Alfredo Harp Helu
• Favorite: Diamondbacks (-119)
• Underdog: Padres (-101)
• Over/under: 16

How to Watch Diamondbacks vs. Padres

• TV Channel: ARID and SDPA
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Diamondbacks vs. Padres: Betting the Moneyline

• The Diamondbacks have won six of the eight games they were favored on the moneyline this season (75%).
• San Diego has been underdogs in 10 games this season and has come away with the win five times (50%) in those contests.
• Arizona has a record of 4-2 when favored by -119 or more by bookmakers this season.
• The Padres have a win-loss record of 5-5 when favored by -101 or worse by oddsmakers this year.
• The Diamondbacks have an implied moneyline win probability of 54.3% in this game.
• The Padres have an implied victory probability of 50.2% according to the moneyline set by sportsbooks for this matchup.

Diamondbacks vs. Padres: Betting the Spread & Total

• The Diamondbacks have played in 25 games with set over/under, and have combined with opponents to go over the total 15 times (15-9-1).
• San Diego and its opponents have hit the over in 10 of its 25 games with a total this season.
• The Diamondbacks have gone 18-7-0 ATS this season.
• In 25 games with a line this season, the Padres have a mark of 16-9-0 against the spread.