Diamondbacks vs. White Sox Dunkel MLB Picks, Predictions and Prop Bets - April 22

The Chicago White Sox are looking for another big outing from a batter on a hot streak versus the Arizona Diamondbacks on Wednesday at 9:40 p.m. ET, at Chase Field. Munetaka Murakami is riding a four-game homer streak. Eduardo Rodriguez (1-0, 1.96 ERA) will start for the Diamondbacks, who are 13-10 this season and third in the NL West. Anthony Kay (1-0, 2.60 ERA) is starting for the White Sox, who are 9-14 and fourth in the AL Central.

Bookmakers have made the Diamondbacks a decent moneyline favorite (-154) at home over the White Sox (+127). The contest has a total set at 9.

Diamondbacks vs. White Sox Odds, Game Time

• Game day: Wednesday, April 22, 2026
• Game time: 9:40 p.m. ET
• Location: Phoenix, Arizona
• Stadium: Chase Field
• Favorite: Diamondbacks (-154)
• Underdog: White Sox (+127)
• Over/under: 9

How to Watch Diamondbacks vs. White Sox

• TV Channel: ARID and CHSN
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Diamondbacks vs. White Sox: Betting the Moneyline

• The Diamondbacks have won 83.3% of the games this season when they were the moneyline favorite (5-1).
• Chicago has been pegged as an underdog in 23 games this year and has walked away with the win nine times (39.1%) in those games.
• Arizona has not entered a game this season with shorter moneyline odds than -154.
• This season, the White Sox have come away with a win six times in 13 chances when named as an underdog of at least +127 or worse on the moneyline.
• The implied moneyline probablility for this matchup gives the Diamondbacks a 60.6% chance to win.
• The moneyline set for this matchup implies the White Sox have a 44.1% chance of walking away with the win.

Diamondbacks vs. White Sox: Betting the Spread & Total

• The Diamondbacks have combined with opponents to hit the over on the total 14 times this season for a 14-8-1 record against the over/under.
• Chicago and its opponents have hit the over in 15 of its 23 games with a total this season.
• The Diamondbacks have put together a 17-6-0 record ATS this season (covering 73.9% of the time).
• The White Sox have posted a record of 11-12-0 against the spread this season.