Alabama vs. LSU Dunkel NCAA Football Picks, Predictions and Odds - Nov. 8

Two of the nation's top defenses meet when the No. 4 Alabama Crimson Tide (7-1) bring college football's 20th-ranked scoring defense into a matchup with the LSU Tigers (5-3), who have the No. 22 scoring defense, on Saturday, November 8, 2025. The Crimson Tide are massive, 10-point favorites.

The Crimson Tide beat the South Carolina Gamecocks, 29-22, in their last contest.

The Tigers' most recent contest was against the Texas A&M Aggies, and they lost by a score of 49-25.

Alabama vs. LSU Predictions

For the upcoming contest between the Alabama Crimson Tide and LSU Tigers, computer-calculated against-the-spread, over/under, and score predictions are below, based on data from Dunkel Index.

• Pick ATS: Crimson Tide (- 10)
• Pick OU: Over (49.5)
  
• Prediction: Crimson Tide 34 - Tigers 20

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Alabama vs. LSU Moneylines

Snag a peek below at the latest moneylines for the Crimson Tide-Tigers game.

• Alabama Moneyline: -370
• LSU Moneyline: +293

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Alabama Betting Insights

• Alabama has a 6-1 record in games it was favored on the moneyline (winning 85.7% of those games).
• Alabama has a record of 4-1 when it has played as a moneyline favorite with odds of -370 or shorter (80%).
• The Crimson Tide and their opponents have combined to score more than 49.5 points in five of eight games this season.
• The average total in Crimson Tide matchups this year is 51.8, 2.3 more points than this game's over/under.
• The Crimson Tide score the 41st-most points in college football this season, while the Tigers' offense puts up the 98th-most.

LSU Betting Insights

• LSU has won one of the four games it has played as an underdog this season.
• LSU has not been a bigger underdog this season than the +293 moneyline set for this game.
• LSU has played three games this season that ended with a combined score higher than 49.5 points.
• LSU has a 51.6-point average over/under in their matchups this season, 2.1 more points than this game's point total.

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Key Stats for Alabama vs. LSU

• Over their last four meetings, Alabama has collected three wins against LSU.
• The two teams have gone over the total on two occasions while sharing an even 2-2 record in their games against the spread.
• Defensively, the Crimson Tide have been a top-25 unit, ranking 24th-best by allowing just 312.8 yards per game. They rank 50th on offense (410.5 yards per game).
• Alabama ranks 30th in points scored this year (34.4 points per game), but has been shining on the other side of the ball, ranking 20th-best in the FBS with 18.3 points allowed per game.
• The Tigers rank 95th with 355.3 total yards per contest on offense, and they rank 35th with 325.9 total yards surrendered per game on the defensive side of the ball.
• LSU's defensive unit has been leading the charge for the team, as it ranks 22nd-best in the FBS with 18.9 points conceded per contest. In terms of offense, it is compiling 25.5 points per game, which ranks 83rd.