USC vs. Iowa Dunkel NCAA Football Picks, Predictions and Odds - Nov. 15

The No. 17 USC Trojans (7-2) take the seventh-ranked scoring offense in college football into a matchup with the Iowa Hawkeyes (6-3), who have the No. 6 scoring defense, on Saturday, November 15, 2025. The Trojans are 6.5-point favorites.

Against the Northwestern Wildcats in their most recent game, the Trojans won 38-17.

Last time out, the Hawkeyes fell to the Oregon Ducks, with 18-16 being the final score.

USC vs. Iowa Predictions

For predictions on the upcoming game between the USC Trojans and Iowa Hawkeyes, computer-derived against-the-spread, over/under, and score predictions are below, sourced from Dunkel Index.

• Pick ATS: Hawkeyes (+ 6.5)
• Pick OU: Over (48.5)
  
• Prediction: Trojans 29 - Hawkeyes 28

Bet now on FanDuel Sportsbook!

USC vs. Iowa Moneylines

Take a look below at the most recent moneylines for the Trojans-Hawkeyes game.

• USC Moneyline: -255
• Iowa Moneyline: +207

Pick with the best in the business! Get free picks for every game, every week at the Dunkel Index.

USC Betting Insights

• USC has won seven of the eight games it was listed as the moneyline favorite this season (87.5%).
• USC has won all five games it has played as a moneyline favorite with odds of -255 or shorter.
• Trojans games this season have gone over this contest's total of 48.5 points seven times.
• Trojans contests this year have an average point total of 58.7, 10.2 more points than this game's over/under.
• The Trojans score the 11th-most points in college football this season, while the Hawkeyes' offense racks up the 64th-most.

Iowa Betting Insights

• Iowa has been the underdog in three games this season, and it has failed to win any of those contests.
• Iowa has played as an underdog of +207 or more once this season and lost that game.
• Iowa games this season have had a combined scoring total higher than 48.5 points in three of nine outings.
• Iowa's games this season have had an average of 43.3 points, 5.2 fewer points than this game's point total.

Watch USC vs. Iowa on Fubo.

Key Stats for USC vs. Iowa

• On the offensive side of the ball, the Trojans have been a top-25 unit, ranking second-best in the FBS by totaling 503.2 yards per game. They rank 50th on defense (346.8 yards allowed per game).
• USC ranks 43rd in scoring defense this year (21.8 points allowed per game), but has been playing really well on offense, ranking seventh-best in the FBS with 39.6 points per game.
• The Hawkeyes rank 16th-worst in total yards per game on offense (309.1), but at least they've been playing well on the other side of the ball, ranking fourth-best in total yards surrendered per contest (250.2).
• Iowa has been excelling on the defensive side of the ball, giving up just 13.7 points per game (sixth-best). On offense, it ranks 60th by posting 29.6 points per game.