Santa Clara vs. San Francisco Dunkel Predictions & Vegas Odds - Feb. 21

In a matchup featuring one of the hottest teams in college basketball, the Santa Clara Broncos (22-6, 13-2 WCC, 9-1 in their last 10) face the San Francisco Dons (15-14, 7-9 WCC) at War Memorial at the Sobrato Center on February 21, 2026. The Broncos are favorites by 7.5 points. The point total is set at 158.5 for the matchup.

Santa Clara dropped its most recent outing 94-86 against Gonzaga on Saturday. Christian Hammond's team-high 16 points paced Santa Clara in the loss. San Francisco lost its most recent outing 80-59 against Gonzaga on Wednesday. San Francisco got a team-leading 16 points from Tyrone Riley IV in the loss.

Santa Clara vs. San Francisco Odds and Game Time

• When: Saturday, February 21, 2026 at 10 p.m. ET
• Where: War Memorial at the Sobrato Center in San Francisco, California
• Spread favorite: Santa Clara -7.5
• Moneyline favorite: Santa Clara -325
• Moneyline underdog: San Francisco +260
• Over/Under: 158.5 points

How to watch Santa Clara vs. San Francisco

• TV Channel: CBS Sports Network
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Santa Clara vs. San Francisco

• This season, Santa Clara's games have seen a combined score higher than this matchup's 158.5-point total 14 times.
• This season, seven of San Francisco's games have ended with a combined score higher than 158.5 points.
• The over/under for the matchup of 158.5 is 0.3 points more than the combined points per game averages for the Broncos (83.7 points per game) and the Dons (74.5 points per game).
• The 144.9 points per game these two teams allow their opponents to score on average this season are 13.6 fewer than the 158.5 total in this contest.
• On average, the over/under in Santa Clara's games is 2.9 fewer points than the over/under of 158.5 in this matchup.
• San Francisco's games have an average over/under of 147.4 points this season, 11.1 points lower than the over/under for this contest.

Betting the Spread: Santa Clara vs. San Francisco

• Santa Clara is 15-12-0 against the spread this year.
• The Broncos have an ATS record of 6-9 in their 15 games as a favorite of 7.5 points or more so far this season.
• In San Francisco's 28 games this season, it has 12 wins against the spread.
• The Dons have covered the spread twice this season when underdogs by 7.5 points or more (in five chances).
• San Francisco is 4-9 against the spread, and 8-5 overall, at home.
• At home, San Francisco is 3-6 ATS as a 7.5-point underdog or greater.
• In away games, Santa Clara is 7-2 overall and 5-4 against the spread.
• Santa Clara has one win ATS (1-3) as 7.5-point favorites or more away from home.

Betting the Moneyline: Santa Clara vs. San Francisco

• Santa Clara has been the moneyline favorite in 23 games this season and won 20 (87%) of those contests.
• The Broncos have a record of 14-1, a 93.3% win rate, when favored by -325 or more by bookmakers this season.
• The moneyline for this contest implies a 76.5% chance of a victory for Santa Clara.
• San Francisco has come away with three wins in the 11 contests it has been listed as the moneyline underdog this season.
• The Dons have yet to win this season when listed as an underdog of +260 or worse on the moneyline this season.
• San Francisco has an implied victory probability of 27.8% according to the moneyline set by oddsmakers for this matchup.