Giants vs. Padres Dunkel MLB Picks, Predictions and Prop Bets - April 1

The San Francisco Giants aim to finish off a sweep of a three-game series versus the San Diego Padres, at 4:10 p.m. ET on Wednesday. Adrian Houser (0-0, 0.00 ERA) will start for the Giants, who are 2-3 this season and third in the NL West. Nick Pivetta (0-1, 18.00 ERA) is the expected starter for the Padres, who are 1-4 and fifth in the NL West.

Despite playing away from their home ballpark, the Giants are favored to win (-133) over the Padres (+112). The game's over/under is set at 7.5.

Giants vs. Padres Odds, Game Time

• Game day: Wednesday, April 1, 2026
• Game time: 4:10 p.m. ET
• Location: San Diego, California
• Stadium: Petco Park
• Favorite: Giants (-133)
• Underdog: Padres (+112)
• Over/under: 7.5

How to Watch Giants vs. Padres

• TV Channel: SDPA and NBCS-BA
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Giants vs. Padres: Betting the Moneyline

• The Giants won 53.3% of the games last season they were the moneyline favorite (49-43).
• San Diego won in 36, or 50%, of the 72 contests it was named as odds-on underdogs in last year.
• When playing as a moneyline favorite with odds of -133 or shorter last year, San Francisco had a record of 41-27 (60.3%).
• Last season, San Diego came away with a win 19 times in 43 chances when named as an underdog of at least +112 or longer on the moneyline.
• Based on this game's moneyline, the Giants have an implied win probability of 57.1%.
• The Padres have an implied victory probability of 47.2% according to the moneyline set by oddsmakers for this matchup.

Giants vs. Padres: Betting the Spread & Total

• The Giants combined with their opponents to hit the over on the total 75 times last season for a 75-77-10 record against the over/under.
• San Diego and its opponents hit the over in 69 of its 165 games with a total last season.
• The Giants put together a 76-86-0 record ATS last season (covering 46.9% of the time).
• The Padres had an against the spread record of 89-76-0 in 165 games with a line last season.