Padres vs. Mariners Dunkel MLB Picks, Predictions and Prop Bets - April 15

The San Diego Padres take a six-game winning streak into a home contest versus the Seattle Mariners at 9:40 p.m. ET on Wednesday. Randy Vasquez (1-0, 1.02 ERA) will start for the Padres, who are 11-6 this season and second in the NL West. Emerson Hancock (2-1, 2.04 ERA) is the expected starter for the Mariners, who are 8-10 and fourth in the AL West.

Per the moneyline, the matchup between the Padres (-113) and Mariners (-106) looks like a close one. The game has an over/under set at 8 runs.

Padres vs. Mariners Odds, Game Time

• Game day: Wednesday, April 15, 2026
• Game time: 9:40 p.m. ET
• Location: San Diego, California
• Stadium: Petco Park
• Favorite: Padres (-113)
• Underdog: Mariners (-106)
• Over/under: 8

How to Watch Padres vs. Mariners

• TV Channel: SDPA and SEAM
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Padres vs. Mariners: Betting the Moneyline

• The Padres have won 75% of the games this season when they were the moneyline favorite (6-2).
• Seattle has been pegged as an underdog in three games this year and has walked away with the win one time (33.3%) in those games.
• San Diego has a record of 6-2 in games when bookmakers favor them by at least -113 on the moneyline.
• This season, the Mariners have come away with a win one times in three chances when named as an underdog of at least -106 or longer on the moneyline.
• The Padres have a 53.1% chance to win this contest based on the moneyline's implied probability.
• Bookmakers have implied with the moneyline set for this matchup that the Mariners have a 51.5% chance of pulling out a win.

Padres vs. Mariners: Betting the Spread & Total

• In the 17 games in which oddsmakers have set an over/under for the Padres, they have combined with opponents to go over the total eight times (8-8-1).
• Seattle and its opponents have hit the over in eight of its 18 games with a total this season.
• The Padres have a 12-5-0 record against the spread this season (covering 70.6% of the time).
• The Mariners are 7-11-0 against the spread in their 18 games with a line set by sportsbooks this season.