Padres vs. Twins Dunkel MLB Picks, Predictions and Prop Bets - Aug. 22

The Minnesota Twins visit the San Diego Padres at 8:40 p.m. ET on Saturday. Casey Mize (5-7, 3.18 ERA) will start for the Padres, who are 69-60 this season and second in the NL West. Dean Kremer (2-4, 5.40 ERA) is starting for the Twins, who are 63-66 and second in the AL Central.

At home, the Padres are favored to win on the moneyline (-139) over the Twins (+122). The game's total is set at 8.5.

Padres vs. Twins Odds, Game Time

• Game day: Saturday, August 22, 2026
• Game time: 8:40 p.m. ET
• Location: San Diego, California
• Stadium: Petco Park
• Favorite: Padres (-139)
• Underdog: Twins (+122)
• Over/under: 8.5

How to Watch Padres vs. Twins

• TV Channel: SDPA and MNNT
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Padres vs. Twins: Betting the Moneyline

• The Padres have been the moneyline favorite 56 total times this season. They've finished 32-24 in those games.
• Minnesota has won in 38, or 45.8%, of the 83 contests it has been named as odds-on underdogs in this year.
• San Diego has a record of 16-8, a 66.7% win rate, when favored by -139 or more by sportsbooks this season.
• This year, the Twins have won 17 of 36 games when listed as at least +122 or worse on the moneyline.
• The Padres have a 58.2% chance to win this matchup based on the moneyline's implied probability.
• The moneyline set for this matchup implies the Twins have a 45% chance of coming away with a victory in the contest.

Padres vs. Twins: Betting the Spread & Total

• The Padres have played in 129 games with a set over/under, and have combined with their opponents to go over the total 56 times (56-69-4).
• So far this season, Minnesota and its opponents have hit the over in 68 of its 129 games with a total.
• The Padres are 72-57-0 ATS this season.
• The Twins are 70-59-0 against the spread in their 129 games with a line set by sportsbooks this season.