Padres vs. Twins Dunkel MLB Picks, Predictions and Prop Bets - Aug. 21

The Minnesota Twins ride a three-game winning streak into a home matchup versus the San Diego Padres, at 9:40 p.m. ET on Friday. Randy Vasquez (8-6, 4.30 ERA) gets the start for the Padres, who are 68-60 this season and second in the NL West. Connor Prielipp (3-6, 5.34 ERA) is expected to start for the Twins, who are 63-65 and second in the AL Central.

The Padres are moderate favorites on the moneyline (-118) at home over the Twins (+104). The game has an over/under set at 8 runs.

Padres vs. Twins Odds, Game Time

• Game day: Friday, August 21, 2026
• Game time: 9:40 p.m. ET
• Location: San Diego, California
• Stadium: Petco Park
• Favorite: Padres (-118)
• Underdog: Twins (+104)
• Over/under: 8

How to Watch Padres vs. Twins

• TV Channel: SDPA and MNNT
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Padres vs. Twins: Betting the Moneyline

• The Padres have a 31-24 record in games they were listed as the moneyline favorite (winning 56.4% of those games).
• Minnesota has been underdogs in 82 games this season and has come away with the win 38 times (46.3%) in those contests.
• San Diego has a record of 25-19 in games when oddsmakers favor them by at least -118 on the moneyline.
• This year, the Twins have won 33 of 67 games when listed as at least +104 or worse on the moneyline.
• The Padres have a 54.1% chance to win this contest based on the moneyline's implied probability.
• The moneyline set for this matchup implies the Twins have a 49% chance of walking away with the win.

Padres vs. Twins: Betting the Spread & Total

• The Padres have played in 128 games with over/under set, and have combined with opponents to go over the total 56 times (56-69-3).
• Minnesota and its opponents have gone over the total this season in 68 of its 128 opportunities.
• The Padres have put together a 71-57-0 record against the spread this season (covering 55.5% of the time).
• The Twins are 70-58-0 against the spread in their 128 games with a line set by sportsbooks this season.