Padres vs. Athletics Dunkel MLB Picks, Predictions and Prop Bets - May 22

The San Diego Padres and Athletics square off in the first of a three-game series on Friday at Petco Park, at 9:40 p.m. ET. Walker Buehler (3-2, 5.01 ERA) will start for the Padres, who are 29-20 this season and second in the NL West. Jeffrey Springs (3-4, 3.93 ERA) is expected to start for the Athletics, who are 26-24 and first in the AL West.

With the Athletics (+106) visiting, the Padres (-127) are a solid favorite on the moneyline. The game has an over/under set at 8 runs.

Padres vs. Athletics Odds, Game Time

• Game day: Friday, May 22, 2026
• Game time: 9:40 p.m. ET
• Location: San Diego, California
• Stadium: Petco Park
• Favorite: Padres (-127)
• Underdog: Athletics (+106)
• Over/under: 8

How to Watch Padres vs. Athletics

• TV Channel: SDPA and NBCS-CA
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Padres vs. Athletics: Betting the Moneyline

• The Padres have won 58.3% of the games this season when they were favored on the moneyline (14-10).
• The Athletics have come away with 19 wins in the 33 contests they have been listed as the underdogs in this season.
• The Padres have a record of 11-8, a 57.9% win rate, when they're favored by -127 or more by bookmakers this season.
• This year, the Athletics have won 15 of 25 games when listed as at least +106 or better on the moneyline.
• The implied moneyline probablility in this matchup gives the Padres a 55.9% chance to win.
• The Athletics have an implied victory probability of 48.5% according to the moneyline set by sportsbooks for this matchup.

Padres vs. Athletics: Betting the Spread & Total

• The Padres have combined with their opponents to go over the total 21 times this season for a 21-26-2 record against the over/under.
• Games involving the Athletics have gone over the total set by oddsmakers in 23 of 50 chances this season.
• The Padres have collected a 28-21-0 record against the spread this season (covering 57.1% of the time).
• In 50 games with a line this season, the Athletics have a mark of 27-23-0 against the spread.