Padres vs. Athletics Dunkel MLB Picks, Predictions and Prop Bets - May 22

The San Diego Padres host the Athletics to open a three-game series at Petco Park, with first pitch at 9:40 p.m. ET on Friday. Walker Buehler (3-2, 5.01 ERA) gets the start for the Padres, who are 29-20 this season and second in the NL West. Jeffrey Springs (3-4, 3.93 ERA) is expected to start for the Athletics, who are 26-24 and first in the AL West.

With the Athletics (+107) visiting, the Padres (-128) are a solid favorite on the moneyline. The total for this contest is set at 8.

Padres vs. Athletics Odds, Game Time

• Game day: Friday, May 22, 2026
• Game time: 9:40 p.m. ET
• Location: San Diego, California
• Stadium: Petco Park
• Favorite: Padres (-128)
• Underdog: Athletics (+107)
• Over/under: 8

How to Watch Padres vs. Athletics

• TV Channel: SDPA and NBCS-CA
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Padres vs. Athletics: Betting the Moneyline

• The Padres have won 14 of the 24 games they were favored on the moneyline this season (58.3%).
• The Athletics have been underdogs in 33 games this season and have come away with the win 19 times (57.6%) in those contests.
• This season, the Padres have won 11 of their 19 games, or 57.9%, when favored by at least -128 on the moneyline.
• This season, the Athletics have come away with a win 15 times in 25 chances when named as an underdog of at least +107 or longer on the moneyline.
• The Padres have a 56.1% chance to win this game based on the moneyline's implied probability.
• The Athletics have an implied victory probability of 48.3% according to the moneyline set by sportsbooks for this matchup.

Padres vs. Athletics: Betting the Spread & Total

• The Padres have played in 49 games with an over/under set, and have combined with their opponents to go over the total 21 times (21-26-2).
• The Athletics and their opponents have hit the over in 23 of their 50 games with a total this season.
• The Padres are 28-21-0 ATS this season.
• The Athletics have posted a record of 27-23-0 against the spread this season.