Pirates vs. Cardinals Dunkel MLB Picks, Predictions and Prop Bets - May 21

The Pittsburgh Pirates and St. Louis Cardinals play a rubber match on Thursday at 1:15 p.m. ET, with the series deadlocked at 1-1. Braxton Ashcraft (2-2, 3.09 ERA) will start for the Pirates, who are 25-24 this season and fifth in the NL Central. Dustin May (3-4, 4.81 ERA) is starting for the Cardinals, who are 28-20 and second in the NL Central.

Even though the Pirates are playing on the road at the Cardinals, they are currently favored on the moneyline at -122, compared to the home team at +102. The contest has an over/under set at 7.

Pirates vs. Cardinals Odds, Game Time

• Game day: Thursday, May 21, 2026
• Game time: 1:15 p.m. ET
• Location: St. Louis, Missouri
• Stadium: Busch Stadium
• Favorite: Pirates (-122)
• Underdog: Cardinals (+102)
• Over/under: 7

How to Watch Pirates vs. Cardinals

• TV Channel: CARD and SportsNet PT
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Pirates vs. Cardinals: Betting the Moneyline

• The Pirates have won 18 of the 29 games they were favored on the moneyline this season (62.1%).
• St. Louis has been victorious in 24, or 60%, of the 40 contests it has been chosen as underdogs in this season.
• Pittsburgh has a record of 13-11 in games when bookmakers favor them by at least -122 on the moneyline.
• This year, the Cardinals have won 19 of 32 games when listed as at least +102 or worse on the moneyline.
• The Pirates have an implied moneyline win probability of 55% in this matchup.
• Sportsbooks have implied with the moneyline set for this matchup that the Cardinals have a 49.5% chance of pulling out a win.

Pirates vs. Cardinals: Betting the Spread & Total

• The Pirates have played in 49 games with set over/under, and have combined with opponents to go over the total 26 times (26-22-1).
• St. Louis' games have gone over the total in 19 of its 48 chances.
• The Pirates are 25-24-0 against the spread this season.
• The Cardinals have an against the spread record of 30-18-0 in 48 games with a line this season.