Phillies vs. Padres Dunkel MLB Picks, Predictions and Prop Bets - May 25

The Philadelphia Phillies visit the San Diego Padres to open a three-game series at Petco Park, with first pitch at 6:40 p.m. ET on Monday. Jesus Luzardo (3-4, 4.85 ERA) gets the start for the Phillies, who are 26-27 this season and third in the NL East. Randy Vasquez (5-2, 2.96 ERA) is starting for the Padres, who are 31-21 and second in the NL West.

The moneyline odds for the Phillies (-118) versus the Padres (-102) are tight. The game has an over/under set at 7 runs.

Phillies vs. Padres Odds, Game Time

• Game day: Monday, May 25, 2026
• Game time: 6:40 p.m. ET
• Location: San Diego, California
• Stadium: Petco Park
• Favorite: Phillies (-118)
• Underdog: Padres (-102)
• Over/under: 7

How to Watch Phillies vs. Padres

• TV Channel: SDPA and NBCS-PH
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Phillies vs. Padres: Betting the Moneyline

• The Phillies have put together a 21-17 record in games they were favored on the moneyline (winning 55.3% of those games).
• San Diego has won in 14, or 58.3%, of the 24 contests it has been named as odds-on underdogs in this year.
• Philadelphia is 20-16 this season when entering a game favored by -118 or more on the moneyline.
• The Padres have a mark of 12-10 in contests where bookmakers favor them by -102 or worse on the moneyline.
• The implied moneyline probablility for this matchup gives the Phillies a 54.1% chance to win.
• The Padres have an implied victory probability of 50.5% according to the moneyline set for this matchup.

Phillies vs. Padres: Betting the Spread & Total

• The Phillies have played in 53 games with set over/under, and have combined with opponents to go over the total 24 times (24-27-2).
• So far this season, San Diego and its opponents have hit the over in 22 of its 52 games with a total.
• The Phillies have gone 17-36-0 against the spread this season.
• In 52 games with a line this season, the Padres have a mark of 30-22-0 against the spread.