Phillies vs. Guardians Dunkel MLB Picks, Predictions and Prop Bets - May 22

The Philadelphia Phillies host the Cleveland Guardians to open a three-game series at Citizens Bank Park, with first pitch at 6:40 p.m. ET on Friday. Cristopher Sanchez (5-2, 1.82 ERA) will start for the Phillies, who are 25-25 this season and second in the NL East. Gavin Williams (6-3, 3.67 ERA) is starting for the Guardians, who are 30-22 and first in the AL Central.

The Phillies (-189) are moneyline favorites at home over the Guardians (+157). The over/under in this contest is set at 6.5.

Phillies vs. Guardians Odds, Game Time

• Game day: Friday, May 22, 2026
• Game time: 6:40 p.m. ET
• Location: Philadelphia, Pennsylvania
• Stadium: Citizens Bank Park
• Favorite: Phillies (-189)
• Underdog: Guardians (+157)
• Over/under: 6.5

How to Watch Phillies vs. Guardians

• TV Channel: NBCS-PH and CLEG
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Phillies vs. Guardians: Betting the Moneyline

• The Phillies have a 20-16 record in games they were favored on the moneyline (winning 55.6% of those games).
• Cleveland has been victorious in 13, or 56.5%, of the 23 contests it has been chosen as underdogs in this season.
• Philadelphia has a record of 6-1 in games when oddsmakers favor them by at least -189 on the moneyline.
• The Guardians have a win-loss record of 2-2 when favored by +157 or worse by bookmakers this year.
• The Phillies have an implied moneyline win probability of 65.4% in this game.
• The Guardians have an implied victory probability of 38.9% according to the moneyline set by sportsbooks for this matchup.

Phillies vs. Guardians: Betting the Spread & Total

• The Phillies have played in 50 games with over/under set, and have combined with opponents to go over the total 24 times (24-24-2).
• Games involving Cleveland have gone over the total set by oddsmakers in 26 of 52 chances this season.
• The Phillies have covered just 32% of their games this season, going 16-34-0 ATS.
• The Guardians are 29-23-0 against the spread in their 52 games with a line set by sportsbooks this season.