Twins vs. Astros Dunkel MLB Picks, Predictions and Prop Bets - May 20

Byron Buxton and Yordan Alvarez face off in a showdown of top-five power hitters when the Minnesota Twins and Houston Astros meet at Target Field, at 1:40 p.m. ET on Wednesday. Buxton has 15 homers (fifth in league) for the Twins, and Alvarez ranks fifth with 15 round-trippers for the Astros. Joe Ryan (2-3, 3.20 ERA) will start for the Twins, who are 22-27 this season and third in the AL Central. Mike Burrows (2-5, 5.72 ERA) is the expected starter for the Astros, who are 20-30 and fourth in the AL West.

The Astros (+125) take their show on the road to face the favored Twins (-150). The game has an over/under of 8 runs.

Twins vs. Astros Odds, Game Time

• Game day: Wednesday, May 20, 2026
• Game time: 1:40 p.m. ET
• Location: Minneapolis, Minnesota
• Stadium: Target Field
• Favorite: Twins (-150)
• Underdog: Astros (+125)
• Over/under: 8

How to Watch Twins vs. Astros

• TV Channel: MNNT and SCHN
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Twins vs. Astros: Betting the Moneyline

• The Twins have won six of the 15 games they were listed as the moneyline favorite this season (40%).
• Houston has been victorious in 15, or 44.1%, of the 34 contests it has been chosen as underdogs in this season.
• Minnesota has played as favorites of -150 or more once this season and lost that game.
• This season, the Astros have been victorious four times in 15 chances when named as an underdog of at least +125 or worse on the moneyline.
• The Twins have a 60% chance to win this matchup based on the moneyline's implied probability.
• Sportsbooks have implied with the moneyline set for this matchup that the Astros have a 44.4% chance of pulling out a win.

Twins vs. Astros: Betting the Spread & Total

• The Twins have had an over/under set by bookmakers 49 times, and have combined with opponents to go over the total in 27 of those games (27-19-3).
• So far this season, Houston and its opponents have hit the over in 28 of its 50 games with a total.
• The Twins have a 25-24-0 record ATS this season (covering 51% of the time).
• The Astros have posted a record of 20-30-0 against the spread this season.