Rams vs. Bills Week 5 Dunkel NFL Picks, Predictions and Odds

The Los Angeles Rams (2-2) are considered favorites (-3) according to the oddsmakers ahead of their game versus the Buffalo Bills (3-1) on October 12, 2026, starting at 8:15 p.m. ET, airing on ABC/ESPN. The total for this one is set at 55.5 points.

On offense, the Rams rank 19th in the NFL with 21.3 points per game. Meanwhile, they rank ninth in points allowed (247.5 points allowed per contest). In terms of total offense, the Bills rank eighth in the NFL (386.3 total yards per game) and 27th on defense (372.3 total yards allowed per game).

Rams vs. Bills Odds and Game Time

• Date: Monday, October 12, 2026
• Time: 8:15 p.m. ET
• City: Inglewood, California
• Venue: SoFi Stadium
• Total: 55.5 points
• Spread: Rams -3
• Moneyline: Rams (-162), Bills (+136)

How to watch Rams vs. Bills

• TV Channel: ABC/ESPN

Betting the Over/Under: Rams vs. Bills

• Only one of the Rams four outings has gone over 55.5 points.
• Los Angeles games have gone over the point total twice this season.
• The Bills and their opponents have scored more than 55.5 combined points twice this season.
• Buffalo games have gone over the point total three out of four times this year.
• These two teams are scoring 53.1 points per game between them, 2.4 fewer than this matchup's over/under.
• Combined, these teams give up 47.6 points per game, 7.9 fewer points than this matchup's total.

Betting the Spread: Rams vs. Bills

• Los Angeles has a record of 1-3-0 against the spread this season.
• Los Angeles has covered the spread once this season (1-2 ATS) when playing as at least 3-point favorites.
• The Bills have covered three times in four matchups with a spread this year.

Betting the Moneyline: Rams vs. Bills

• Los Angeles has gone 2-2 in games they were favored on the moneyline (winning 50% of those games).
• The Bills will play as the underdog for the first time this season.
• When playing as a moneyline favorite with odds of -162 or shorter, Los Angeles has a 2-1 record (winning 66.7% of its games).
• Buffalo has not entered a game this season with longer moneyline odds than +136.
• Based on this game's moneyline, the Rams have an implied win probability of 61.8%.

Dunkel Prediction for Rams vs. Bills

For more expert NFL picks, visit our Dunkel Index NFL Picks and Predictions.