Rams vs. Cardinals Week 6 Dunkel NFL Picks, Predictions and Odds

The Arizona Cardinals (1-4) will be trying to end a four-game losing streak against the Los Angeles Rams (2-3). The Rams are heavy favorites (-12.5). The expected point total for the matchup is set at 52.5.

The Rams are putting up 23.8 points per game on offense, which ranks them 13th in the NFL. On defense, they rank 20th, giving up 24.0 points per game. The Cardinals rank 23rd with 301.2 total yards per game on offense, and they rank 26th with 363.4 total yards given up per contest on defense.

Rams vs. Cardinals Odds and Game Time

• Date: Sunday, October 18, 2026
• Time: 4:05 p.m. ET
• City: Inglewood, California
• Venue: SoFi Stadium
• Total: 52.5 points
• Spread: Rams -12.5
• Moneyline: Rams (-901), Cardinals (+600)

How to watch Rams vs. Cardinals

• TV Channel: FOX

Betting the Over/Under: Rams vs. Cardinals

• In two games this season, the Rams and their opponents have combined to score more than 52.5 points.
• So far this season, three of Los Angeles' five games have hit the over.
• The Cardinals have played three games this season that ended with a combined score higher than 52.5 points.
• Arizona games have hit the over three out of five times this year.
• These teams average 45.4 points per game combined, 7.1 less than this game's total.
• Opponents of these teams score 56.4 points per game combined, 3.9 more points than this contest's total.

Betting the Spread: Rams vs. Cardinals

• Los Angeles has covered the spread just once in five games this season.
• The Cardinals have covered twice in five chances against the spread this season.
• The Rams have covered the spread once at home, and are 1-2 overall there this season.
• The Cardinals have two wins against the spread and are 1-2 overall, on the road.

Betting the Moneyline: Rams vs. Cardinals

• Los Angeles has won two of the five games it was listed as the moneyline favorite this season (40%).
• The Cardinals have entered the game as underdogs four times this season and won once.
• Los Angeles has yet to play as a moneyline favorite of -901 or shorter.
• Arizona has not entered a game this season with longer moneyline odds than +600.
• The Rams have a 90.0% chance to win this matchup based on the moneyline's implied probability.

Dunkel Prediction for Rams vs. Cardinals

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